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A novel L1/2 regularization shooting method for Cox’s proportional hazards model

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Abstract

Nowadays, a series of methods are based on a L 1 penalty to solve the variable selection problem for a Cox’s proportional hazards model. In 2010, Xu et al. have proposed a L 1/2 regularization and proved that the L 1/2 penalty is sparser than the L 1 penalty in linear regression models. In this paper, we propose a novel shooting method for the L 1/2 regularization and apply it on the Cox model for variable selection. The experimental results based on comprehensive simulation studies, real Primary Biliary Cirrhosis and diffuse large B cell lymphoma datasets show that the L 1/2 regularization shooting method performs competitively.

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References

  • Akaike H (1973) Information theory and an extension of the maximum likelihood principle. In: Petrov BN, Caki F (eds) Second International Symposium on Information Theory. Akademiai Kiado, Budapest, pp 267–281

    Google Scholar 

  • Brier GW (1950) Verification of forecasts expressed in terms of probability. Mon Weather Rev 78:1–3

    Article  Google Scholar 

  • Candes E, Tao T (2007) The Dantzig selector: statistical estimation when p is much larger than n. Ann Stat 35:2313–2351

    Article  MATH  MathSciNet  Google Scholar 

  • Chen S, Donoho DL, Saunders M (2001) Atomic decomposition by basis pursuit. SIAM Rev 43:129–159

    Article  MATH  MathSciNet  Google Scholar 

  • Cox DR (1972) Regression models and life-tables. J R Statist Soc B 34:187–220

    MATH  Google Scholar 

  • Cox DR (1975) Partial likelihood. Biometrika 62:269–276

    Article  MATH  MathSciNet  Google Scholar 

  • Dickson E, Grambsch P, Fleming T, Fisher L, Langworthy A (1989) Prognosis in primary biliary cirrhosis: model for decision making. Hepatology 10:1–7

    Article  Google Scholar 

  • Donoho DL, Elad E (2003) Maximal sparsity representation via l1 minimization. Proc Natl Acal Sci 100:2197–2202

    Article  MATH  MathSciNet  Google Scholar 

  • Donoho DL, Huo X (2001) Uncertainty principles and ideal atomic decomposition. IEEE Trans Inf Theory 47:2845–2862

    Article  MATH  MathSciNet  Google Scholar 

  • Fan J, Heng P (2004) Nonconcave penalty likelihood with a diverging number of parameters. Ann Stat 32(2):928–961

    MATH  Google Scholar 

  • Fan J, LI R (2001) Variable selection via nonconcave penalized likelihood and its oracle properties. J Am Stat Assoc 96:1348–1360

    Article  MATH  MathSciNet  Google Scholar 

  • Fan J, LI R (2002) Variable selection for Cox’s proportional hazards model and frailty model. Ann Stat 30:74–99

    Article  MATH  MathSciNet  Google Scholar 

  • Faraggi D, Simon R (1998) Bayesian variable selection method for censored survival data. Biometrics 54:1475–1485

    Article  MATH  MathSciNet  Google Scholar 

  • Fu W (1998) Penalized regression: the bridge versus the lasso. J Comp Graph Stat 7:397–416

    Google Scholar 

  • Graf E, Schmoor C, Sauerbrei W, Schumacher M (1999) Assessment and comparison of prognostic classification schemes for survival data. Stat Med 18:2529–2545

    Article  Google Scholar 

  • Gui J, Li H (2005) Penalized Cox regression analysis in the high-dimensional and low-sample size settings, with applications to microarray gene expression data. Bioinformatics 21:3001–3008

    Article  Google Scholar 

  • Heagerty PJ et al (2000) Time dependent ROC curves for censored survival data and a diagnostic marker. Biometrics 56:337–344

    Article  MATH  MathSciNet  Google Scholar 

  • Huang J, Harrington D (2002) Penalized partial likelihood regression for right censored data with bootstrap selection of the penalty parameter. Biometrics 58:781–791

    Article  MATH  MathSciNet  Google Scholar 

  • Ibrahim JG, Chen M-H, Maceachern SN (1999) Bayesian variable selection for proportional hazards models. Can J Stat 27:701–717

    Article  MATH  MathSciNet  Google Scholar 

  • Qian J, Li B, Chen PY (2010) Generating survival data in the simulation studies of cox model. Inf Comput (ICIC) 4:93–96

    Google Scholar 

  • Rosenwald A et al (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. New Engl J Med 346:1937–1946

    Article  Google Scholar 

  • Sauerbrei W, Schumacher M (1992) A bootstrap resampling procedure for model building: application to the cox regression model. Stat Med 11:2093–2109

    Article  Google Scholar 

  • Schwarz G (1978) Estimating the dimension of a model. Ann Stat 6:461–464

    Article  MATH  Google Scholar 

  • Smyth P (2001) Model selection of probabilistic clustering using cross-validated likelihood. Stat and Comput 10:63–72

    Article  Google Scholar 

  • Therneau TM, Grambsch PM (2000) Modeling survival data: Extending the Cox model. Springer-Verlag Inc., NewYork

    Book  Google Scholar 

  • Tibshirani R (1996) Regression shrinkage and selection via the lasso. J R Stat Soc B 58:267–288

    MATH  MathSciNet  Google Scholar 

  • Tibshirani R (1997) The lasso method for variable selection in the Cox model. Stat Med 16:385–395

    Article  Google Scholar 

  • Van Der Laan MJ, Dudoit S, Keles S (2003) Asymptotic Optimality of likelihood based Cross Validation, Technical Report, Division of Biostatistics, University of California, Berkeley

  • Verwij PJM, Van Houwelingen JC (1993) Cross validation in survival analysis. Stat Med 12:2305–2314

    Article  Google Scholar 

  • Xu ZB, Zhang H, Wang Y, Chang XY (2010) L 1/2 regularization. Sci China, ser F 40(3):1–11

    Google Scholar 

  • Zhang HH, Lu W (2007) Adaptive Lasso for Cox’s proportional hazards model. Biometrika 94:691–703

    Article  MATH  MathSciNet  Google Scholar 

  • Zhao P, Yu B (2007) Stagewise Lasso. J Mach Learn Res 8:2701–2726

    MATH  MathSciNet  Google Scholar 

  • Zou H (2006) The adaptive Lasso and its oracle properties. J Am Stat Assoc 101(476):1418–1429

    Article  MATH  Google Scholar 

  • Zou H, Hastie T (2005) Regularization and variable selection via the elastic net. J R Stat Soc B 67:301–320

    Article  MATH  MathSciNet  Google Scholar 

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Acknowledgments

This work was supported by the Macau Science and Technology Develop Funds (Grant No. 017/2010/A2) of Macau SAR of China and the National Natural Science Foundation of China (Grant No. 11171272).

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Correspondence to Yong Liang.

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Communicated by G. Acampora.

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Luan, XZ., Liang, Y., Liu, C. et al. A novel L1/2 regularization shooting method for Cox’s proportional hazards model. Soft Comput 18, 143–152 (2014). https://doi.org/10.1007/s00500-013-1042-6

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