Abstract
Obstructive sleep apnea is a syndrome which is characterized by the decrease in air flow or respiratory arrest depending on upper respiratory tract obstructions recurring during sleep and often observed with the decrease in the oxygen saturation. The aim of this study was to determine the connection between the respiratory arrests and the photoplethysmography (PPG) signal in obstructive sleep apnea patients. Determination of this connection is important for the suggestion of using a new signal in diagnosis of the disease. Thirty-four time-domain features were extracted from the PPG signal in the study. The relation between these features and respiratory arrests was statistically investigated. The Mann–Whitney U test was applied to reveal whether this relation was incidental or statistically significant, and 32 out of 34 features were found statistically significant. After this stage, the features of the PPG signal were classified with k-nearest neighbors classification algorithm, radial basis function neural network, probabilistic neural network, multilayer feedforward neural network (MLFFNN) and ensemble classification method. The output of the classifiers was considered as apnea and control (normal). When the classifier results were compared, the best performance was obtained with MLFFNN. Test accuracy rate is 97.07 % and kappa value is 0.93 for MLFFNN. It has been concluded with the results obtained that respiratory arrests can be recognized through the PPG signal and the PPG signal can be used for the diagnosis of OSA.
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Acknowledgments
This research was supported by The Scientific and Technical Research Council of Turkey (TUBITAK) through The Research Support Programs Directorate (ARDEB) with project number of 115E657, and project name of “A New System for Diagnosing Obstructive Sleep Apnea Syndrome by Automatic Sleep Staging Using Photoplethysmography (PPG) Signals and Breathing Scoring” and by The Coordination Unit of Scientific Research Projects of Sakarya University. Produced from the doctoral thesis “Development of A New System for The Diagnosis of Sleep Staging and Sleep Apnea Syndrome” under the consultancy of the authors (Mehmet Recep Bozkurt), this study was supported by the SAU Commission of Scientific Research Projects (Project No.: 2014-50-02-022). The ethics committee report numbered 16214662/050.01.04/70 from Sakarya University Deanship of Faculty of Medicine, and the data use permission numbered 94556916/904/151.5815 from T.C. Ministry of Health Turkey Public Hospitals Authority Sakarya Province General Secretariat of Association of Public Hospitals were received to perform the study.
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Uçar, M.K., Bozkurt, M.R., Bilgin, C. et al. Automatic detection of respiratory arrests in OSA patients using PPG and machine learning techniques. Neural Comput & Applic 28, 2931–2945 (2017). https://doi.org/10.1007/s00521-016-2617-9
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DOI: https://doi.org/10.1007/s00521-016-2617-9