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Finite dose skin penetration: a comparison of concentration-depth profiles from experiment and simulation

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Computing and Visualization in Science

Abstract

In this paper we present a mathematical diffusion model describing the transient transdermal penetration of two non-volatile substances, the lipophilic flufenamic acid and the hydrophilic caffeine, after finite dosing in an aqueous vehicle system. A striking feature of this microscopic diffusion model is its ability to predict concentration-depth profiles. Relevant input parameters are obtained from a previously published infinite dose study (Naegel et al in Eur J Pharm Biopharm 68:368–379, 2008; Hansen et al in Eur J Pharm Biopharm 68:352–367, 2008). The quality of the model has been evaluated by comparing the concentration-depth profiles in stratum corneum (SC) and deeper skin layers of the experiment with those of the simulation. The results from the experiment and the simulation are in good agreement. The study addresses benefits and shortcomings of the model, and discusses future perspectives such as incorporating different morphological regions of the SC.

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Authors and Affiliations

  1. Goethe-Center for Scientific Computing, Goethe-University, Frankfurt am Main, Germany

    Arne Naegel, Michael Heisig & Gabriel Wittum

  2. Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany

    Tsambika Hahn, Ulrich F. Schaefer & Claus-Michael Lehr

  3. Department of Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University, Saarbruecken, Germany

    Claus-Michael Lehr

Authors
  1. Arne Naegel
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  2. Tsambika Hahn
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  3. Ulrich F. Schaefer
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  4. Claus-Michael Lehr
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  5. Michael Heisig
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  6. Gabriel Wittum
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Corresponding author

Correspondence to Michael Heisig.

Additional information

Arne Naegel, Tsambika Hahn contributed equally to this work.

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Naegel, A., Hahn, T., Schaefer, U.F. et al. Finite dose skin penetration: a comparison of concentration-depth profiles from experiment and simulation. Comput. Visual Sci. 14, 327–339 (2011). https://doi.org/10.1007/s00791-012-0186-8

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  • DOI: https://doi.org/10.1007/s00791-012-0186-8

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