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Fabrication of micro-gelatin fiber utilizing coacervation method

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Abstract

Biotechnology has drastically been advanced by the development of iPS and ES cells, which are representative forms induced pluripotent stem cells. In the micro/nano bio field, the development of cells and Taylor-made medicine for a potential treatment of incurable diseases has been a center of attention. The melting point of gelatin is between 25 and 33 °C, and the sol–gel transition occurs in low temperature. This makes the deformation of this useful biomaterial easy. The examples of gelatin fiber applications are suture threads, blood vessel prosthesis, cell-growth-based materials, filter materials, and many others. Because the cell size differs depending on the species and applications, it is essential to fabricate gelatin fibers of different diameters. In this paper, we have developed a fabrication method for gelatin fibers the coacervation method. We fabricated narrow gelatin fibers having a diameter over 10 μm.

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Acknowledgement

This work was supported by The Precise Measurement Technology Promotion Foundation, Urakami Foundation for Food and Food Culture Promotion, JSPS Kakenhi Grant Number 254202224, and Waseda University Grants for Special Research Projects (Project Number: 2014S-097). For the present study, we were offered G-1017 K gelatin for free from manufacture by Nitta Gelatin Incorporated.

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Authors and Affiliations

  1. Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan

    Takafumi Arai

  2. Undergraduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan

    Ryuichiro Tanaka & Shinjiro Umezu

  3. Faculty of Science and Engineering, TWIns, Waseda University, Tokyo, Japan

    Katsuhisa Sakaguchi

Authors
  1. Takafumi Arai
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  2. Ryuichiro Tanaka
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  3. Katsuhisa Sakaguchi
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  4. Shinjiro Umezu
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Correspondence to Shinjiro Umezu.

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Arai, T., Tanaka, R., Sakaguchi, K. et al. Fabrication of micro-gelatin fiber utilizing coacervation method. Artif Life Robotics 22, 197–202 (2017). https://doi.org/10.1007/s10015-016-0344-z

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  • DOI: https://doi.org/10.1007/s10015-016-0344-z

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