Abstract
Cancer chemotherapy-induced peripheral neuropathy (CIPN) deteriorates the patient’s quality of life, often resulting in discontinuation of treatment with potentially effective chemotherapy. Contact needle therapy (CNT) is one of the traditional Japanese acupuncture methods based on the concept of Kampo (Japanese traditional) medicine. CNT on CIPN has been considered effective empirically, but an objective evaluation has proven difficult. We have focused on the oxygen saturation besides the symptom score. We have already proposed optical path-length matrix method (OPLM) for estimating oxygen saturation of the skin, which may help in locating peripheral tissue damage, including neuronal damage. Four patients with CIPN were treated with CNT. The severity of CIPN was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) ver. 4 and FACT/GOG-Ntx before and after CNT. We also measured oxygen saturation and hemoglobin concentration at the right toe-tip. Correlations among the values were calculated as correlation coefficients. There were significantly improvements in FACT/GOG-Ntx and hemoglobin post-CNT than in pre-CNT (p < 0.05). The oxygen saturation showed broad correlation (0.5 < |r| < 1) with hemoglobin. The oxygen saturation of skin reflects tissue injury and blood stagnation status, and can help in objective evaluation by measuring skin color spectrum. CNT might be considered as one of the safe and effective alternative therapeutic options for CIPN. Our method of evaluation using skin color spectrum information integrates, in a sense, the inspection in Kampo (Japanese traditional medicine) therapy and scientific methodology.
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References
Quan D, Teener JW, Farrar JT (2002) Neuromuscular dysfunction and palliative care. In: Berger AM, Portenoy RK, Weissman DE (eds) Principles & practice of palliative care & supportive oncology, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 545–554
Kaley TJ, Deangelis LM (2009) Therapy of chemotherapy-induced peripheral neuropathy. Br J Haematol 145(1):3–14
Sioka C, Kyritsis AP (2009) Central and peripheral nervous system toxicity of common chemotherapeutic agents. Cancer Chemother Pharmacol 63(5):761–767
Rowinsky EK, Donehower RC (1995) Paclitaxel (taxol). N Engl J Med 332(15):1004–1014
LoMonaco M, Milone M, Batocchi AP, Padua L, Restuccia D, Tonali P (1992) Cisplatin neuropathy: clinical course and neurophysiological findings. J Neurol 239(4):199–204
Pasetto LM, D’Andrea MR, Rossi E, Monfardini S (2006) Oxaliplatin-related neurotoxicity: how and why? Crit Rev Oncol Hematol 59(2):159–168
Pachman DR, Barton DL, Watson JC, Loprinzi CL (2011) Chemotherapy-induced peripheral neuropathy: prevention and treatment. Clin Pharmacol Ther 90(3):377–387
Schroeder S, Meyer-Hamme G, Epplée S (2012) Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography. Acupunct Med 30(1):4–7
Ogawa K, Ogawa M, Nishijima K, Tsuda M, Nishimura G (2013) Efficacy of contact needle therapy for chemotherapy-induced peripheral neuropathy. Evid Based Complement Altern Med. https://doi.org/10.1155/2013/928129
Yamamoto S, Fujiwara I, Yamauchi M, Tsumura N, Ogawa-Ochiai K (2012) Optical path-length matrix method for estimating skin spectrum. Opt Rev 19(6):361–365
Sato Y, Hanawa T, Arai M et al (2005) Introduction to Kampo—Japanese traditional medicine. The Japan Society for Oriental Medicine. Elsevier, Tokyo
Yamamoto S, Tsumura N, Nakaguchi T et al (2011) Regional image analysis of the tongue color spectrum. Int J Comput Assist Radiol Surg 6(1):143–152
Yamamoto S, Tsumura N, Nakaguchi T et al (2011) Principal component vector rotation of the tongue color spectrum to predict “mibyou” (disease-oriented state). Int J Comput Assist Radiol Surg 6(2):209–215
Yamamoto S, Ishikawa Y, Nakaguchi T et al (2012) Temporal changes in tongue color as criterion for tongue diagnosis in kampo medicine. Forsch Komplementmed 19(2):80–85
Tsumura N, Kawabuchi M, Haneishi H, Miyake Y (2001) Mapping pigmentation in human skin from multi-channel visible spectrum image by inverse optical scattering technique. J Imaging Sci Technol 45(5):444–450
Akaho R, Hirose M, Tsumura N (2018) Evaluation of the robustness of estimating five components from a skin spectral image. Opt Rev 25(2):81–189
Colson K, Doss DS, Swift R, Tariman J, Thomas TE (2004) Bortezomib, a newly approved proteasome inhibitor for the treatment of multiple myeloma: nursing implications. Clin J Oncol Nurs 8:473–480
Kanda Y (2013) Investigation of the freely available easy-to-use software EZR for medical statistics. Bone Marrow Transplant 48:452–458
Yamamoto S, Tsumura N, Yoshizaki T, Ogawa K (2014) Oxygen saturation of skin reflects blood flow and stagnation. Artif Life Robot 19:170–175
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Ogawa-Ochiai, K., Shirai, A., Tsuda, M. et al. Optical examination of the efficacy of contact needle therapy for chemotherapy-induced peripheral neuropathy: integration of inspection in Kampo therapy with color spectrum information. Artif Life Robotics 24, 1–5 (2019). https://doi.org/10.1007/s10015-018-0447-9
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DOI: https://doi.org/10.1007/s10015-018-0447-9