Abstract
Dry eye syndrome is a prevalent disease which affects a wide range of the population and has a negative impact on their daily activities, such as driving or working with computers. Its diagnosis and monitoring require a battery of tests which measure different physiological characteristics. One of these clinical tests consists in capturing the appearance of the tear film using the Doane interferometer. Once acquired, the interferometry images are classified into one of the five categories considered in this research. The variability in appearance makes the use of a computer-based analysis system highly desirable. For this reason, a general methodology for the automatic analysis and categorization of interferometry images is proposed. The development of this methodology included a deep study based on several techniques for image texture analysis, three color spaces and different machine learning algorithms. The adequacy of this methodology was demonstrated, achieving classification rates over 93 %. Also, it provides unbiased results and allows important time savings for experts.
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References
Moss SE (2000) Prevalence of and risk factors for dry eye syndrome. Archiv Ophthalmol 118(9):1264–1268
Jie Y, Xu L, Wu YY, Jonas JB (2008) Prevalence of dry eye among adult Chinese in the Beijing Eye Study. Eye 23(3):688–693
Smith JA (2007) The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop. Ocular Surf 5(2):93–107
Nichols KK, Nichols JJ, Zadnik K (2000) Frequency of dry eye diagnostic test procedures used in various modes of ophthalmic practice. Cornea 19(4):477–482
Bron AJ (2001) Diagnosis of dry eye. Surv Ophthalmol 45(2).
Bron AJ, Smith JA, Calonge M (2007) Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop. Ocular Surf 5(2):108–152
Lemp MA (2007) The definition and classification of dry eye disease: report of the definition and classification Subcommittee of the International Dry Eye WorkShop. Ocular Surf 5(2):75–92
Nichols KK, Mitchell GL, Zadnik KT (2004) The repeatability of clinical measurements of dry eye. Cornea 23(3):272–285
Rolando M, Zierhut M (2001) The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol 45(Supplement 2(0)):S203–S210
Korb D, Craig J, Doughty M, Guillon J, Smith G, Tomlinson A (2002) The tear film structure, function and clinical examination, Chap. 2. Butterworth Heinemann, UK
Doane MG (1989) An instrument for in vivo tear film interferometry. Optometry Vis Sci 66(6):383–388
Guillon JP, Guillon M (1997) Tearscope plus clinical hand book and tearscope plus instructions. Keeler Ltd., Keeler Inc, Windsor, Broomall
Thai LC, Tomlinson A, Doane MG (2004) Effect of contact lens materials on tear physiology. Optometry Vis Sci 81(3):194–204
Bron AJ, Tiffany JM, Gouveia SM, Yokoi N, Voon LW (2004) Functional aspects of the tear film lipid layer. Exp Eye Res 78:347–360
Freeman MH, Hull CC (2014) Interference and optical films
McCann LC, Tomlinson A, Pearce EI, Papa V (2012) Effectiveness of artificial tears in the management of evaporative dry eye. Cornea 31(1):1–5
Fagehi RA, Tomlinson A, Manihilov V (2012) Comparative study of soft contact lenswetting in vitro after storage in Biotrue MPS. Contact Lens Anterior Eye 35(1)
CMEX-1300x camera. Euromex Microscopen BV. Arnhem, The Netherlands
ImageFocus Capture and Analysis software, Euromex Microscopen BV, Arnhem, The Netherlands
ImageToAvi software, ASW Software, Mesa, AZ, US.
Gonzalez R, Woods R (2008) Digital image processing. Pearson, Prentice Hall
Remeseiro B, Penas M, Barreira N, Mosquera A, Novo J, García-Resúa C (2013) Automatic classification of the interferential tear film lipid layer using colour texture analysis. Comput Methods Progr Biomed 111:93–102
McLaren K (1976) The development of the CIE 1976 (L*a*b*) uniform colour-space and colour-difference formula. J Soc Dyers Colourists 92(9):338–341
Sangwine SJ, Horne REN (1998) The colour image processing handbook. Chapman & Hall, London
Hering E (1964) Outlines of a theory of the light sense. Harvard University Press, Cambridge
Borer S, Ssstrunk S (2002) Opponent color space motivated by retinal processing. In: Proc. IS&T first European conference on color in graphics, imaging and vision (CGIV), vol 1, pp 187–189
Ramos L, Penas M, Remeseiro B, Mosquera A, Barreira N, Yebra-Pimentel E (2011) Texture and color analysis for the automatic classification of the eye lipid layer. LNCS: advances in computational intelligence (international work conference on artificial neural networks-IWANN 2011) 6692:66–73
Gabor D (1946) Theory of communication. J Inst Electr Eng 93:429–457
Grigorescu SE, Petkov N, Kruizinga P (2002) Comparison of texture features based on Gabor filters. IEEE Trans Image Process 11(10):1160–1167
Mallat SG (1989) A theory for multiresolution signal decomposition: the wavelet representation. IEEE Trans Pattern Anal Mach Intell 11:674–693
Fdez-Sarria A, Ruiz LA, Recio JA (2005) Study of methods based on wavelets for texture classification of high resolution images. In: Procs of 25th EARSeL symposium. Global developments in environmental earth observation from space, pp 19–25
Remeseiro B, Ramos L, Penas M, Martínez E, Penedo MG, Mosquera A (2011) Colour texture analysis for classifying the tear film lipid layer: a comparative study. In: International conference on digital image computing: techniques and applications (DICTA), pp 268–273, Noosa, Australia
Daubechies I (1992) Ten lectures on wavelets. SIAM, CBMS series
Woods JW (1972) Two-dimensional discrete markovian fields. IEEE Trans Inf Theory 18(2):232–240
Çesmeli E, Wang D (2001) Texture segmentation using Gaussian–Markov random fields and neural oscillator networks. IEEE Trans Neural Netw 12
Haralick RM, Shanmugam K, Dinstein I (1973) Texture features for image classification. IEEE Trans Syst Man Cybern Syst Man Cybern 3:610–621
Mitchell TM (1997) Machine learning. McGraw-Hill, New York
Remeseiro B, Penas M, Mosquera A, Novo J, Penedo MG, Yebra-Pimentel E (2012) Statistical comparison of classifiers applied to the interferential tear film lipid layer automatic classification. Comput Math Methods Med 1–10:2012
Jensen F (1996) An introduction to bayesian networks. Springer, Berlin
Friedman N, Geiger D, Goldszmidt M (1997) Bayesian network classifiers. Machine Learn 29:131–163.
Biau G (2012) Analysis of a random forests model. J Machine Learn Res 13:1063–1095
Breiman L (2001) Random Forests. Machine Learning 45(1):5–32
Burges CJC (1998) A tutorial on support vector machines for pattern recognition. Data Mining Knowl Discov 2:121–167
VOPTICAL_GCU, VARPA optical dataset annotated by optometrists from the Department of Life Sciences, Glasgow Caledonian University (UK), 2012. http://www.varpa.es/voptical_gcu.html. Accessed July 2014
Chang C, Lin C (2011) LIBSVM: a library for support vector machines. ACM Trans Intell Syst Technol 2:27:1–27:27
Hall M, Frank E, Holmes G, Pfahringer B, Reutemann P, Witten IH (2009) The weka data mining software: an update. ACM SIGKDD Explor Newslett 11(1):10–18
Rodriguez J, Perez A, Lozano J (2010) Sensitivity analysis of k-fold cross-validation in prediction error estimation. IEEE Trans Pattern Anal Mach Intell 32:569–575
Goulden CH (1956) Methods of statistical analysis, 2nd edn. Wiley, Chapman & Hall, New York
Wilcoxon F (1945) Individual comparisons by ranking methods. Biometrics Bull 1(6):80–83
Hogg R, Ledolter J (1987) Engineering Statistics. MacMillan, New York
Demšar J (2006) Statistical comparisons of classifiers over multiple data sets. J Mach Learn Res 7:1–30
Friedman M (1937) The use of ranks to avoid the assumption of normality implicit in the analysis of variance. J Am Stat Assoc 32:675–701
Nemenyi PB (1963) Distribution-free multiple comparisons. PhD thesis, Princeton University
Fawcett T (2006) An Introduction to ROC Analysis. Pattern Recognit Lett 27(8):861–874
Efron N (1997) Clinical application of grading scales for contact lens complications. Optician 213:26–34
Efron N, Morgan PB, Katsara SS (2001) Validation of grading scales for contact lens complications. Ophthal Physiol Optics 21(1):17–29
Efron N (2011) A survey of the use of grading scales for contact lens complications in optometric practice. Clin Exper Optometry 94(2):193–199
Acknowledgments
This research has been partially funded by the Secretaría de Estado de Investigación of the Spanish Government and FEDER funds of the European Union through the research projects TIN2011-25476 and PI12/02075; and by the Consellería de Cultura, Educación e Ordenación Universitaria of the Xunta de Galicia through the agreement for the Singular Research Center CITIC.
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Remeseiro, B., Oliver, K.M., Tomlinson, A. et al. Automatic grading system for human tear films. Pattern Anal Applic 18, 677–694 (2015). https://doi.org/10.1007/s10044-014-0402-x
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DOI: https://doi.org/10.1007/s10044-014-0402-x