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A critical review and meta-analysis of the perceptual pseudoneglect across psychiatric disorders: Is there a continuum?

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Abstract

The phenomenon known as “perceptual pseudoneglect” refers to the leftward bias in visuospatial attention in non-clinical samples, possibly as a consequence of right hemisphere dominance for visuospatial attention. The degree of such a lateralized visuospatial attention bias is often assessed using the line bisection task. Interestingly, various psychiatric disorders may influence the expression of this phenomenon. The aim of this paper was to perform a critical appraisal of the literature on the expression of the perceptual pseudoneglect across all psychiatric disorders accompanied by meta-analytical evaluation of the data. Moreover, we will discuss whether this phenomenon may be considered as a trait marker across different psychiatric disorders.

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References

  • Arduino LS, Previtali P, Girelli L (2010) The centre is not in the middle: evidence from line and word bisection. Neuropsychologia 48:2140–2146

    Article  PubMed  Google Scholar 

  • Barnett KJ (2006) Schizophrenia and rightward bias in line bisection. Laterality 11:36–42

    PubMed  Google Scholar 

  • Benwell CS, Thut G, Grant A, Harvey M (2014) A rightward shift in the visuospatial attention vector with healthy aging. Front Aging Neurosci 6:113

    Article  PubMed Central  PubMed  Google Scholar 

  • Bisiach E, Luzzatti C (1978) Unilateral neglect of representational space. Cortex 14:129–133

    Article  CAS  PubMed  Google Scholar 

  • Bowers D, Heilman KM (1980) Pseudoneglect: effects of hemispace on a tactile line bisection task. Neuropsychologia 18:491–498

    Article  CAS  PubMed  Google Scholar 

  • Cavezian C, Rossetti Y, Danckert J, D’amato T, Dalery J, Saoud M (2007) Exaggerated leftward bias in the mental number line of patients with schizophrenia. Brain Cogn 63:85–90

    Article  PubMed  Google Scholar 

  • Cavézian C, Michel C, Rossetti Y, Danckert J, d’Amato T, Saoud M (2011) Visuospatial processing in schizophrenia: does it share common mechanisms with pseudoneglect? Laterality 16:433–461

    PubMed  Google Scholar 

  • Crow TJ (2010) A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. Laterality 15:289–303

    CAS  PubMed  Google Scholar 

  • DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  CAS  PubMed  Google Scholar 

  • Fink GR, Marshall JC, Weiss PH, Toni I, Zilles K (2002) Task instructions influence the cognitive strategies involved in line bisection judgements: evidence from modulated neural mechanisms revealed by fMRI. Neuropsychologia 40:119–130

    Article  CAS  PubMed  Google Scholar 

  • Gazzaniga MS (2000) Cerebral specialization and interhemispheric communication: Does the corpus callosum enable the human condition? Brain 123:1293–1326

    Article  PubMed  Google Scholar 

  • Gooch D, Snowling M, Hulme C (2011) Time perception, phonological skills and executive function in children with dyslexia and/or ADHD symptoms. J Child Psychol Psychiatr 52:195–203

    Article  Google Scholar 

  • Hari R, Renvall H, Tanskanen T (2001) Left minineglect in dyslexic adults. Brain 124:1373–1380

    Article  CAS  PubMed  Google Scholar 

  • He W, Chai H, Zhang Y, Yu S, Chen W, Wang W (2010) Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression. Int J Med Sci 7:224–231

    Article  PubMed Central  PubMed  Google Scholar 

  • Heilman KM, Valenstein E, Watson RT (2000) Neglect and related disorders. Semin Neurol 20:463–470

    Article  CAS  PubMed  Google Scholar 

  • Heim S, Kissler J, Elbert T, Rockstroh B (2004) Cerebral lateralization in schizophrenia and dyslexia: neuromagnetic responses to auditory stimuli. Neuropsychologia 42:692–697

    Article  PubMed  Google Scholar 

  • Hellige JB (1990) Hemispheric asymmetry. Annu Rev Psychol 41:55–80

    Article  CAS  PubMed  Google Scholar 

  • Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560

    Article  PubMed Central  PubMed  Google Scholar 

  • Hunter JE, Schmidt FL (2000) Fixed effects vs random effects meta-analysis models: implications for cumulative research knowledge. Int J Sel Assess 8:275–292

    Article  Google Scholar 

  • Jewell G, Mccourt ME (2000) Pseudoneglect: a review and meta-analysis of performance factors in line bisection tasks. Neuropsychologia 38:93–110

    Article  CAS  PubMed  Google Scholar 

  • Kato Y, Muramatsu T, Kato M, Shibukawa Y, Shintani M, Mimura M (2011) Magnetoencephalography study of right parietal lobe dysfunction of the evoked mirror neuron system in antipsychotic-free schizophrenia. PLoS One 6:e28087

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Khandaker GM, Stochl J, Zammit S, Lewis G, Jones PB (2014) A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychol Med 44:3229–3238

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kosslyn SM (1987) Seeing and imagining in the cerebral hemispheres: a computational approach. Psychol Rev 94:148–175

    Article  CAS  PubMed  Google Scholar 

  • Kravetz S, Faust M, Edelman A (1998) Dimensions of schizotypy and lexical decision in the two hemispheres. Personal Individ Differ 25:857–871

    Article  Google Scholar 

  • Leonard CM, Kuldau JM, Maron L, Ricciuti N, Mahoney B, Bengtson M, DeBose C (2008) Identical neural risk factors predict cognitive deficit in dyslexia and schizophrenia. Neuropsychology 22:147–158

    Article  PubMed  Google Scholar 

  • Liouta E, Smith AD, Mohr C (2008) Schizotypy and pseudoneglect: a critical update on theories of hemispheric asymmetries. Cogn Neuropsychiatry 13:112–134

    Article  PubMed  Google Scholar 

  • Lorusso ML, Facoetti A, Toraldo A, Molteni M (2005) Tachistoscopic treatment of dyslexia changes the distribution of visual-spatial attention. Brain Cogn 57:135–142

    Article  PubMed  Google Scholar 

  • Malhotra P, Coulthard EJ, Husain M (2009) Role of right posterior parietal cortex in maintaining attention to spatial locations over time. Brain 132:645–660

    Article  PubMed Central  PubMed  Google Scholar 

  • Marshall JC, Halligan PW (1989) When right goes left: an investigation of line bisection in a case of visual neglect. Cortex 25:503–515

    Article  CAS  PubMed  Google Scholar 

  • Martinez-Cascales I, de la Fuente J, Santiago J Sr, Santiago J Jr (2013) Space and time bisection in schizophrenia. Front Psychol 4:823

    Article  PubMed Central  PubMed  Google Scholar 

  • Mason O, Claridge G (1999) Individual differences in schizotypy and reduced asymmetry using the chimeric faces task. Cogn Neuropsychiatry 4:289–301

    Article  Google Scholar 

  • Mather JA, Neufeld RW, Merskey H, Russell NC (1990) Schizophrenic performance on line bisection: no simple lateralization defects. J Psychiatr Res 24:185–190

    Article  CAS  PubMed  Google Scholar 

  • McCourt ME (2001) Performance consistency of normal observers in forced-choice tachistoscopic visual line bisection. Neuropsychologia 39:1065–1076

    Article  CAS  PubMed  Google Scholar 

  • McCourt ME, Garlinghouse M (2000) Stimulus modulation of pseudoneglect: effect of line geometry. Neuropsychologia 38:520–524

    Article  CAS  PubMed  Google Scholar 

  • Mccourt ME, Jewell G (1999) Visuospatial attention in line bisection: stimulus modulation of pseudoneglect. Neuropsychologia 37:843–855

    Article  CAS  PubMed  Google Scholar 

  • McCourt ME, Garlinghouse M, Slater J (2000) Centripetal versus centrifugal bias in visual line bisection: focusing attention on two hypotheses. Front Biosci 5:D58–D71

    CAS  PubMed  Google Scholar 

  • Mccourt ME, Shpaner M, Javitt DC, Foxe JJ (2008) Hemispheric asymmetry and callosal integration of visuospatial attention in schizophrenia: a tachistoscopic line bisection study. Schizophr Res 102:189–196

    Article  PubMed Central  PubMed  Google Scholar 

  • Michel C, Cavezian C, D’amato T, Dalery J, Rode G, Saoud M, Rossetti Y (2007) Pseudoneglect in schizophrenia: a line bisection study with cueing. Cogn Neuropsychiatry 12:222–234

    Article  PubMed  Google Scholar 

  • Michel C, Bidot S, Bonnetblanc F, Quercia P (2011) Left minineglect or inverse pseudoneglect in children with dyslexia? Neuroreport 22:93–96

    Article  PubMed  Google Scholar 

  • Milner AD, Harvey M (1995) Distortion of size perception in visuospatial neglect. Curr Biol 5:85–89

    Article  CAS  PubMed  Google Scholar 

  • Milner AD, Brechmann M, Pagliarini L (1992) To halve and to halve not: an analysis of line bisection judgements in normal subjects. Neuropsychologia 30:515–526

    Article  CAS  PubMed  Google Scholar 

  • Mohr C, Bracha HS, Brugger P (2003) Magical ideation modulates spatial behavior. J Neuropsychiatry Clin Neurosci 15:168–174

    Article  PubMed  Google Scholar 

  • Najt P, Bayer U, Hausmann M (2012) Atypical lateralisation in emotional prosody in men with schizotypy. Laterality 17:533–548

    PubMed  Google Scholar 

  • Najt P, Bayer U, Hausmann M (2013) Right fronto-parietal dysfunction underlying spatial attention in bipolar disorder. Psychiatry Res 210:479–484

    Article  PubMed  Google Scholar 

  • Nicolson RI, Fawcett AJ, Berry EL, Jenkins IH, Dean P, Brooks DJ (1999) Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet 353:1662–1667

    Article  CAS  PubMed  Google Scholar 

  • Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113

    Article  CAS  PubMed  Google Scholar 

  • Ozel-Kizil ET, Baskak B, Gunes E, Cicek M, Atbasoglu EC (2012) Hemispatial neglect evaluated by visual line bisection task in schizophrenic patients and their unaffected siblings. Psychiatry Res 200:133–136

    Article  PubMed  Google Scholar 

  • Petty RG (1999) Structural asymmetries of the human brain and their disturbance in schizophrenia. Schizophr Bull 25:121–139

    Article  CAS  PubMed  Google Scholar 

  • Polikoff BR, Evans BJ, Legg CR (1995) Is there a visual deficit in dyslexia resulting from a lesion of the right posterior parietal lobe? Ophthalmic Physiol Opt 15:513–517

    Article  CAS  PubMed  Google Scholar 

  • Ramos-Brieva JA, Olivan J, Palomares A, Vela A (1984) Is there right hemisphere dysfunction in major depression? Int J Neurosci 23:103–109

    Article  CAS  PubMed  Google Scholar 

  • Ramus F (2003) Developmental dyslexia: specific phonological deficit or general sensorimotor dysfunction? Curr Opin Neurobiol 13:212–218

    Article  CAS  PubMed  Google Scholar 

  • Rao NP, Arasappa R, Reddy NN, Venkatasubramanian G, Gangadhar BN (2010) Antithetical asymmetry in schizophrenia and bipolar affective disorder: a line bisection study. Bipolar Disord 12:221–229

    Article  PubMed  Google Scholar 

  • Ribolsi M, Lisi G, Di Lorenzo G, Koch G, Oliveri M, Magni V, Pezzarossa B, Saya A, Rociola G, Rubino IA, Niolu C, Siracusano A (2013) Perceptual pseudoneglect in schizophrenia: candidate endophenotype and the role of the right parietal cortex. Schizophr Bull 39:601–607

    Article  PubMed Central  PubMed  Google Scholar 

  • Rolfe MH, Hausmann M, Waldie KE (2006) Hemispheric functioning in children with subtypes of attention-deficit/hyperactivity disorder. J Atten Disord 10:20–27

    Article  PubMed  Google Scholar 

  • Rolfe MH, Hamm JP, Waldie KE (2008) Differences in paper-and-pencil versus computerized line bisection according to ADHD subtype and hand-use. Brain Cogn 66:188–195

    Article  PubMed  Google Scholar 

  • Rubino IA, Frank E, Croce Nanni R, Pozzi D, Lanza di Scalea T, Siracusano A (2009) A comparative study of axis I antecedents before age 18 of unipolar depression, bipolar disorder and schizophrenia. Psychopathology 42:325–332

    Article  PubMed  Google Scholar 

  • Schmitz R, Peigneux P (2011) Age-related changes in visual pseudoneglect. Brain Cogn 76:382–389

    Article  PubMed  Google Scholar 

  • Seki K, Ishiai S, Koyama Y, Sato S (1999) Unassociated responses to two related task demands: a negative factor for improvement of unilateral spatial neglect. Neuropsychologia 37:75–82

    Article  CAS  PubMed  Google Scholar 

  • Sheppard DM, Bradshaw JL, Mattingley JB, Lee P (1999) Effects of stimulant medication on the lateralisation of line bisection judgements of children with attention deficit hyperactivity disorder. J Neurol Neurosurg Psychiatry 66:57–63

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Sireteanu R, Goertz R, Bachert I, Wandert T (2005) Children with developmental dyslexia show a left visual “minineglect”. Vision Res 45:3075–3082

    Article  PubMed  Google Scholar 

  • Suzuki A, Usher M (2009) Individual differences in language lateralisation, schizotypy and the remote-associate task. Personal Individ Differ 46:622–626

    Article  Google Scholar 

  • Tian Y, Wei L, Wang C, Chen H, Jin S, Wang Y, Wang K (2011) Dissociation between visual line bisection and mental number line bisection in schizophrenia. Neurosci Lett 491:192–195

    Article  CAS  PubMed  Google Scholar 

  • Urbanski M, Bartolomeo P (2008) Line bisection in left neglect: the importance of starting right. Cortex 44:782–793

    Article  PubMed  Google Scholar 

  • Vallar G, Bottini G, Paulesu E (2003) Neglect syndromes: the role of the parietal cortex. Adv Neurol 93:293–319

    PubMed  Google Scholar 

  • Varnava A, Dervinis M, Chambers CD (2013) The predictive nature of pseudoneglect for visual neglect: evidence from parietal theta burst stimulation. PLoS One 8:e65851

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Venkatasubramanian G, Jayakumar PN, Keshavan MS, Gangadhar BN (2011) Schneiderian first rank symptoms and inferior parietal lobule cortical thickness in antipsychotic-naive schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 35:40–46

    Article  PubMed  Google Scholar 

  • Vieira S, Quercia P, Bonnetblanc F, Michel C (2013) Space representation in children with dyslexia and children without dyslexia: contribution of line bisection and circle centering tasks. Res Dev Disabil 34:3997–4008

    Article  PubMed  Google Scholar 

  • Waldie KE, Hausmann M (2010) Right fronto-parietal dysfunction in children with ADHD and developmental dyslexia as determined by line bisection judgements. Neuropsychologia 48:3650–3656

    Article  PubMed  Google Scholar 

  • Zhou SY, Suzuki M, Takahashi T, Hagino H, Kawasaki Y, Matsui M, Seto H, Kurachi M (2007) Parietal lobe volume deficits in schizophrenia spectrum disorders. Schizophr Res 89:35–48

    Article  PubMed  Google Scholar 

  • Zivotofsky AZ, Edelman S, Green T, Fostick L, Strous RD (2007) Hemisphere asymmetry in schizophrenia as revealed through line bisection, line trisection, and letter cancellation. Brain Res 1142:70–79

    Article  CAS  PubMed  Google Scholar 

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Ribolsi, M., Di Lorenzo, G., Lisi, G. et al. A critical review and meta-analysis of the perceptual pseudoneglect across psychiatric disorders: Is there a continuum?. Cogn Process 16, 17–25 (2015). https://doi.org/10.1007/s10339-014-0640-2

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