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IA, database of known ligands of aminoacyl-tRNA synthetases

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Abstract

The IA database contains 240 structures of known inhibitors of aminoacyl-tRNA synthetases. Structures can be downloaded in different file formats (mol, sdf, smile, png). The search engine offers possibility of searching for the ligands with a given functional group. Additionally, one can search for ligands that act on selected synthetases and from particular references. The data include information which synthetase a given ligand inhibits together with the inhibition constant (IC50) if known. Database is freely available at http://ia.bioinfo.pl/

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Acknowledgements

Financial support by European Commission and Polish Ministry for Education and Science is acknowledged (BioSapiens project grant number LSHG-CT-2003-503265, and grant number PBZ-MNiI-2/1/2005). MH thanks the Foundation for Polish Science for support via FOCUS program. The authors thank the anonymous referee for the suggestions on improving the IA database.

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Authors and Affiliations

  1. BioInfoBank Institute, ul. Limanowskiego 24A, Poznan, 60-744, Poland

    Mieczyslaw Torchala & Marcin Hoffmann

  2. Faculty of Physics, Adam Mickiewicz University, Umultowska 85, Poznan, 61-614, Poland

    Mieczyslaw Torchala

  3. Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, Poznan, 60-780, Poland

    Marcin Hoffmann

Authors
  1. Mieczyslaw Torchala
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  2. Marcin Hoffmann
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Correspondence to Marcin Hoffmann.

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Torchala, M., Hoffmann, M. IA, database of known ligands of aminoacyl-tRNA synthetases. J Comput Aided Mol Des 21, 523–525 (2007). https://doi.org/10.1007/s10822-007-9135-x

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  • DOI: https://doi.org/10.1007/s10822-007-9135-x

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