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Infragranular layers lead information flow during slow oscillations according to information directionality indicators

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Abstract

The recurrent circuitry of the cerebral cortex generates an emergent pattern of activity that is organized into rhythmic periods of firing and silence referred to as slow oscillations (ca 1 Hz). Slow oscillations not only are dominant during slow wave sleep and deep anesthesia, but also can be generated by the isolated cortical network in vitro, being a sort of default activity of the cortical network. The cortex is densely and reciprocally connected with subcortical structures and, as a result, the slow oscillations in situ are the result of an interplay between cortex and thalamus. Due to this reciprocal connectivity and interplay, the mechanism responsible for the initiation of waves in the corticothalamocortical loop during slow oscillations is still a matter of debate. It was our objective to determine the directionality of the information flow between different layers of the cortex and the connected thalamus during spontaneous activity. With that purpose we obtained multilayer local field potentials from the rat visual cortex and from its connected thalamus, the lateral geniculate nucleus, during deep anaesthesia. We analyzed directionality of information flow between thalamus, cortical infragranular layers (5 and 6) and supragranular layers (2/3) by means of three information theoretical indicators: transfer entropy, symbolic transfer entropy and transcript mutual information. These three indicators coincided in finding that infragranular layers lead the information flow during slow oscillations both towards supragranular layers and towards the thalamus.

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Acknowledgements

We thank Thomas Aschenbrenner and Wolfram Bunk from Complex Systems Consulting (CSYSC) for their contribution to the development of the code. This work was financially supported by the Spanish Ministerio de Economia y Competitividad, grants MTM2012-31698 to J.M. Amigó and BFU2011- 27094 to M.V. Sanchez-Vives, and by the EU PF7 FET CORTICONIC, contract 600806 to M.V. Sanchez-Vives.

Conflict of interests

The authors declare that they have no conflict of interest

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Authors and Affiliations

  1. Centro de Investigación Operativa (CIO), Universidad Miguel Hernández, Elche, Spain

    J. M. Amigó

  2. IngSoft GmbH, Nuremberg, Germany

    R. Monetti

  3. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    N. Tort-Colet & M. V. Sanchez-Vives

  4. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    M. V. Sanchez-Vives

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  1. J. M. Amigó
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  2. R. Monetti
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  3. N. Tort-Colet
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  4. M. V. Sanchez-Vives
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Correspondence to M. V. Sanchez-Vives.

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Amigó, J.M., Monetti, R., Tort-Colet, N. et al. Infragranular layers lead information flow during slow oscillations according to information directionality indicators. J Comput Neurosci 39, 53–62 (2015). https://doi.org/10.1007/s10827-015-0563-7

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  • DOI: https://doi.org/10.1007/s10827-015-0563-7

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