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AMPA/NMDA cooperativity and integration during a single synaptic event

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Abstract

Coexistence of AMPA and NMDA receptors in glutamatergic synapses leads to a cooperative effect that can be very complex. This effect is dependent on many parameters including the relative and absolute number of the two types of receptors and biophysical parameters that can vary among synapses of the same cell. Herein we simulate the AMPA/NMDA cooperativity by using different number of the two types of receptors and considering the effect of the spine resistance on the EPSC production. Our results show that the relative number of NMDA with respect to AMPA produces a different degree of cooperation which depends also on the spine resistance.

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  1. Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, C/O Complesso Olivetti Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy

    Vito Di Maio, Francesco Ventriglia & Silvia Santillo

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  1. Vito Di Maio
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  2. Francesco Ventriglia
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  3. Silvia Santillo
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Correspondence to Vito Di Maio.

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Di Maio, V., Ventriglia, F. & Santillo, S. AMPA/NMDA cooperativity and integration during a single synaptic event. J Comput Neurosci 41, 127–142 (2016). https://doi.org/10.1007/s10827-016-0609-5

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