Abstract
The impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABA A -receptors was found to control stationary asynchronous firing both quantitatively and qualitatively. Quantitative regulation consisted in alterating a current level of stationary population activity while qualitative regulation manifested itself in appearance of resilient asynchronous spiking in case GABA reversal potential exceeded a certain threshold. The study was based on a modified rate model after Wilson and Cowan and backed up with a computer simulation of an explicit network model.
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This research was supported by the Russian Foundation for Basic Research (Project Nos.17-02-01103 A).
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Adamchik, D.A., Kazantsev, V.B. Tonic regulation of stationary asynchronous firing of a neural network. J Comput Neurosci 43, 107–114 (2017). https://doi.org/10.1007/s10827-017-0648-6
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DOI: https://doi.org/10.1007/s10827-017-0648-6