Skip to main content
Log in

A Biomedical System Based on Artificial Neural Network and Principal Component Analysis for Diagnosis of the Heart Valve Diseases

  • Original Paper
  • Published:
Journal of Medical Systems Aims and scope Submit manuscript

Abstract

Listening via stethoscope is a primary method, being used by physicians for distinguishing normally and abnormal cardiac systems. Listening to the voices, coming from the cardiac valves via stethoscope, upon the flow of the blood running in the heart, physicians examine whether there is any abnormality with regard to the heart. However, listening via stethoscope has got a number of limitations, for interpreting different heart sounds depends on hearing ability, experience, and respective skill of the physician. Such limitations may be reduced by developing biomedical based decision support systems. In this study, a biomedical-based decision support system was developed for the classification of heart sound signals, obtained from 120 subjects with normal, pulmonary and mitral stenosis heart valve diseases via stethoscope. Developed system was mainly comprised of three stages, namely as being feature extraction, dimension reduction, and classification. At feature extraction stage, applying Discrete Fourier Transform (DFT) and Burg autoregressive (AR) spectrum analysis method, features, representing heart sounds in frequency domain, were obtained. Obtained features were reduced in lower dimensions via Principal Component Analysis (PCA), being used as a dimension reduction technique. Heart sounds were classified by having the features applied as input to Artificial Neural Network (ANN). Classification results have shown that, dimension reduction, being conducted via PCA, has got positive effects on the classification of the heart sounds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Jiang, Z., and Choi, S., A cardiac sound characteristic waveform method for in-home heart disorder monitoring with electric stethoscope. Expert Syst Appl 31(2):286–298, 2006.

    Article  Google Scholar 

  2. Ahlström, C., Processing of the Phonocardiographic Signal-Methods for the intelligent stethoscope, Ms Thesis, Linköping University, Institue of Techonology, Linköping, Sweden, 2006.

  3. Kara, S., Classification of mitral stenosis from Doppler signals using short time Fourier transform and artificial neural Networks. Expert Syst Appl 33:468–475, 2007.

    Article  Google Scholar 

  4. Güraksın, G.E., Ergün, U., Classification of the Heart Sounds via Artificial Neural Network, International Symposium on Innovations in Intelligent Systems and Applications 507–511, Trabzon Turkey 2009.

  5. Say, Ö., Analysis of heart sounds and classification of by using artificial neural networks, Ms Thesis, Institute of Natural and Applied Science, İstanbul Technical University, İstanbul, Turkey, 2002.

  6. Crawford, M. H., Current diagnosis & treatment in cardiology, chapter 23 of congenital heart disease in adults, 2. McGraw-Hill, USA, 2002. 403 p.

    Google Scholar 

  7. Leung, T. S., White, P. R., Collis, W. B., Brown, E., and Salmon, A. P., Classification of heart sounds using time-frequency method and artificial neural Networks. Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2:988–991, 2006.

    Google Scholar 

  8. Sinha, R. K., Artificial neural network detects changes in electro-encephalogram power spectrum of different sleep-wake states in an animal model of heat stress. Med Biol Eng Comput 41:595–600, 2003.

    Article  Google Scholar 

  9. Kandaswamy, A., Kumar, C., Ramanathan, R., Jayaraman, S., and Malmurugan, N., Neural classification of lung sounds using wavelet coefficients. Comput Biol Med 34(6):523–537, 2004.

    Article  Google Scholar 

  10. O’Rourke, R. A., Cardiovascular disease: foreword. Curr Probl Cardiol 25(11):786–825, 2000.

    Google Scholar 

  11. Sharif, Z., Zainal, M. S., Sha’ameri, A. Z., and Salleh, S. H. S., Analysis and classification of heart sounds and murmurs based on the instantaneous energy and frequency estimations. Tencon 41:130–134, 2000.

    Google Scholar 

  12. El-Segaier, M., Lilja, O., Lukkarinen, S., Sörnmo, L., Sepponen, R., and Pesonen, E., Computer-based detection and analysis of heart sound and murmur. Ann Biomed Eng 33(7):937–942, 2005.

    Article  Google Scholar 

  13. Folland, R., Hines, E. L., Boilot, P., and Morgan, D., Classifying coronary dysfunction using neural networks through cardiovascular auscultation. Med Biol Eng Comput 40:339–343, 2002.

    Article  Google Scholar 

  14. Bhatikar, S. R., DeGroff, C., and Mahajan, R. L., classifier based on the artificial neural network approach for cardiologic auscultation in pediatrics. Artif Intell Med 33:251–260, 2005.

    Article  Google Scholar 

  15. Reed, T. R., Reed, N. E., and Fritzson, P., Heart sound analysis for symptom detection and computer-aided diagnosis. Simul Model Practice Theory 12(2):129–146, 2004.

    Article  Google Scholar 

  16. Sinha, R. K., Aggarwal, Y., and Das, B. N., Backpropagation artificial neural network classifier to detect changes in heart sound due to mitral valve regurgitation. J Med Syst 31:205–209, 2007.

    Article  Google Scholar 

  17. Voss, A., Mix, A., and Huebner, T., Diagnosing aortic valve stenosis by parameter extraction of heart sound signals. Ann Biomed Eng 33:1167–1174, 2005.

    Article  Google Scholar 

  18. Pavlopoulos, S., Stasis, A., Loukis, E., A decision tree-based method for the differential diagnosis of aortic stenosis from mitral regurgitation using heart sounds. BioMed Eng OnLine (June 3) 1–5, 2004, Available at: http://www.biomedical-engineering-online.com/content/3/1/21.

  19. Tetko, I. V., Luik, A. I., and Poda, G. I., Applications of neural networks in structure-activity relationships of a small number of molecules. J Med Chem 36(7):811–814, 1993.

    Article  Google Scholar 

  20. Güraksın, G.E., Classification of the heart sounds via artificial neural network, Ms Thesis, Institute of Natural and Applied Science, Afyon Kocatepe University, Afyonkarahisar, Turkey, 2009.

  21. Cochran, W. T., Cooley, J. W., Favin, D. L., Helms, H. D., Kaenel, R. A., Lang, W. W., Maling, G. C., Nelson, D. E., Rader, C. M., and Welch, P. D., What is the fast fourier transform. Trans Audio Electroacoust 15:45–55, 1967.

    Article  Google Scholar 

  22. Faust, O., Acharya, R. U., Allen, A. R., and Lin, C. M., Analysis of EEG signals during epileptic and alcoholic states using AR modeling techniques. IRBM 29(1):44–52, 2008.

    Article  Google Scholar 

  23. Proakis, J. G., and Manolakis, D. G., Digital signal processing principles, algorithms, and applications. Prentice-Hall, New Jersey, 1996.

    Google Scholar 

  24. Kay, S. M., Modern spectral estimation: theory and application. Prentice-Hall, New Jersey, 1988.

    MATH  Google Scholar 

  25. Akaike, H., A new look at the statistical model identification. IEEE Trans Autom Control 19:716–723, 1974.

    Article  MathSciNet  MATH  Google Scholar 

  26. Ölmez, T., and Dokur, Z., Classification of heart sound using an artificial neural network. Pattern Recogn Lett 24:617–629, 2003.

    Article  Google Scholar 

  27. Türkoğlu, İ., An Intelligent pattern recognition for nonstationary signals based on the time-frequency entropies, Phd Thesis, Institute of Natural and Applied Science, Fırat University, Elazığ, Turkey, 2002.

  28. Haykin, S., Neural Networks. A Comprehensive Foundation. Macmillan College Publishing Company Inc., New York, 1–60 p., 417 p., 1994.

  29. Basheer, I. A., and Hajmeer, M., Artificial neural Networks: Fundementals, computing, design and application. J Microbiol Methods 43:3–31, 2000.

    Article  Google Scholar 

  30. Zhang, Y. X., Artificial neural networks based on principal component analysis input selection for clinical pattern recognition analysis. Talanta 73:68–75, 2007.

    Article  Google Scholar 

  31. Wang, X., and Paliwal, K. K., Feature extraction and dimensionality reduction algorithms and their applications in vowel recognition. Pattern Recogn 36:2429–2439, 2003.

    Article  MATH  Google Scholar 

  32. Beksaç, M. S., Başaran, F., Eskiizmirliler, S., Erkmen, A. M., and Yörükan, S., A computerized diagnostic system for the interpretation of umbilical artery blood flow velocity waveforms. Eur J Obstet Gynecol Reprod Biol 64(1):37–42, 1996.

    Article  Google Scholar 

  33. Akın, M., and Kıymık, M. K., Application of periodogram and AR spectral analysis to EEG signals. J Med Syst 24(4):247–256, 2000.

    Article  Google Scholar 

  34. Seasholtz, M. B., and Kowalski, B., The parsimony principle applied to multivariate calibration. Anal Chim Acta 277:165–177, 1993.

    Article  Google Scholar 

  35. Ferr, L., Selection of components in principal component analysis: a comparison of methods. Computat Stat Data Anal 19:669–682, 1995.

    Article  Google Scholar 

  36. Valle, S., Li, W., and Qin, S. J., Selection of the number of principal components: The variance of the reconstruction error criterion with a comparison to other methods. Ind Eng Chem Res 38:4389–4401, 1999.

    Article  Google Scholar 

  37. Jolliffe, I. T., Principal component analysis, 2nd edition. Springer, New York, 2002.

    MATH  Google Scholar 

  38. Warne, K., Prasad, G., Rezvani, S., and Maguire, L., Statistical and computational intelligence techniques for inferential model development: a comparative evaluation and a novel proposition for fusion. Eng Appl Artif Intell 17:871–885, 2004.

    Article  Google Scholar 

  39. Centor, R. M., Signal detectabilty: The use of ROC curves and their analysis. Med Decis Making 11:102–106, 1991.

    Article  Google Scholar 

Download references

Acknowledgement

This study has been supported by Scientific Research Project of Selcuk University.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Harun Uğuz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uğuz, H. A Biomedical System Based on Artificial Neural Network and Principal Component Analysis for Diagnosis of the Heart Valve Diseases. J Med Syst 36, 61–72 (2012). https://doi.org/10.1007/s10916-010-9446-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10916-010-9446-7

Keywords

Navigation