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Can we Predict Preoperative Tumor Aggressivity with Hemogram Parameters in Renal Cell Carcinoma? a Novel Calculation Method

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Abstract

We aim to investigate the prognostic significance of the hemoglobin X lymphocyte / neutrophil ratio (HLNR) and hemoglobin x lymphocyte / platelet ratio (HLPR) with tumor aggressivity in patients with renal cell carcinoma. We retrospectively analyzed 127 patients’ data who had diagnosed as renal cell carcinoma between 2008 and 2019 in Suleyman Demirel University Hospital. Tumor and patient characteristics, hemoglobin, neutrophil, lymphocyte, platelet values HLNR and HLPR were calculated in preoperative hemogram parameters. The relationship between tumor pathological stage, Fuhrman nuclear grade and tumor necrosis with HLPR and HLNR analyzed with statistically. There was a negative correlation between pathologic stage, Fuhrman nuclear grade and tumor necrosis with HLNR. P values are 0.003, 0.012 and 0.015 respectively. HLNR was lower in patients with high pathologic stage, high Fuhrman nuclear grade and accompanying tumor necrosis positiveness. There was a negative correlation between pathologic stage, Fuhrman nuclear grade and tumor necrosis with HLPR. P values are 0.001, 0.014 and 0.047 respectively. HLPR was lower in patients with high pathologic stage, high Fuhrman nuclear grade and accompanying tumor necrosis positiveness. High pathological stage, high Fuhrman nuclear grade and existence of tumor necrosis are associates with preoperative low HLNR and low HLPR in renal cell carcinoma patients. They can be used as prognostic markers in patients with renal mass preoperatively.

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Author information

Authors and Affiliations

  1. Alanya Alaaddin Keykubat University, School of Medicine, Antalya, Turkey

    Murat Uçar, Ali Akkoç & Murat Topçuoğlu

  2. Süleyman Demirel University, School of Medicine, Isparta, Turkey

    Sedat Soyupek, Taylan Oksay, Alper Özorak, Murat Demir & Alim Koşar

Authors
  1. Murat Uçar
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  2. Sedat Soyupek
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  3. Taylan Oksay
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  4. Alper Özorak
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  5. Ali Akkoç
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  6. Murat Topçuoğlu
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  7. Murat Demir
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  8. Alim Koşar
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Contributions

Conceptualization: Murat Uçar,

Data curation: Murat Uçar, Ali Akkoç, Murat Topçuoğlu.

Formal analysis: Murat Uçar, Sedat Soyupek, Taylan Oksay.

Investigation: Murat Uçar, Murat Demir.

Methodology: Sedat Soyupek, Alim Koşar.

Project administration: Ali Akkoç, Murat Topçuoğlu.

Supervision: Alper Özorak, Alim Koşar.

Validation: Murat Uçar, Murat Demir.

Visualization: Taylan Oksay, Alper Özorak.

Writing – original draft: Murat Uçar.

Writing – review & editing: Sedat Soyupek, Taylan Oksay, Alper Özorak, Alim Koşar.

Corresponding author

Correspondence to Murat Uçar.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Uçar, M., Soyupek, S., Oksay, T. et al. Can we Predict Preoperative Tumor Aggressivity with Hemogram Parameters in Renal Cell Carcinoma? a Novel Calculation Method. J Med Syst 44, 19 (2020). https://doi.org/10.1007/s10916-019-1491-2

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