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Predicting invasive ductal carcinoma tissues in whole slide images of breast Cancer by using convolutional neural network model and multiple classifiers

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Abstract

Breast Cancer (BC) is the common type of cancer found in women which is caused due to the abnormal growth of cells in the breast. Over 80% of the BC type detected till date is the invasive ductal carcinoma (IDC). In this work, a deep learning-based IDC prediction model is proposed based on the convolutional neural network (CNN). The developed deep learning method used a sequential Keras model like conv2D, Maxpooling2D, Dropout, Flatten and Dense. The proposed model is compared with multiple classifiers like logistic regression (LR), random forest (RF), k-nearest neighbor (K-NN), support vector machine (SVM), linear SVM, gaussian naïve bayesian (GNB) and decision tree (DT). The CNN model is generated by using SkLearn, Keras and Tensor flow libraries, and results are organized by MatPlot libraries. After evaluations, the proposed CNN based IDC framework provided 80%–86% of accuracy, 92%–94% of precision, 91%–96% of recall and 94%–96% of F1-score in prediction over the IDC dataset and 91%-94% of accuracy, 91%–95% of precision, 93%–96% of recall and 95%–98% of F1-score over the BreakHis dataset.

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References

  1. Alghodhaifi H, Alghodhaifi A, Alghodhaifi M (2019) Predicting invasive ductal carcinoma in breast histology images using convolutional neural network. In: 2019 IEEE National Aerospace and electronics conference (NAECON), 374-378.

  2. Alzubaidi L, Al-Shamma O, Fadhel MA, Farhan L, Zhang J, Duan Y (2020) Optimizing the performance of breast cancer classification by employing the same domain transfer learning from hybrid deep convolutional neural network model. Electronics 9(3):445

    Article  Google Scholar 

  3. Amakdouf H, Zouhri A, El Mallahi M, Tahiri A, Chenouni D, Qjidaa H (2021) Artificial intelligent classification of biomedical color image using quaternion discrete radial Tchebichef moments. Multimed Tools Appl 80(2):3173–3192

    Article  Google Scholar 

  4. Bolhasani H, Amjadi E, Tabatabaeian M, Jassbi SJ (2020) A histopathological image dataset for grading breast invasive ductal carcinomas. Inform Med Unlocked 19:100341

    Article  Google Scholar 

  5. Cruz-Roa A, Basavanhally A, González F, Gilmore H, Feldman M, Ganesan S, Shih N, Tomaszewski J, Madabhushi A (2014) Automatic detection of invasive ductal carcinoma in whole slide images with convolutional neural networks. In: Medical Imaging 2014: Digital pathology, International Society for Optics and Photonics, 9041: 904103.

  6. Dabeer S, Khan MM, Islam S (2019) Cancer diagnosis in histopathological image: CNN based approach. Inform Med Unlocked 16:100231

    Article  Google Scholar 

  7. Gandomkar Z, Brennan PC, Mello-Thoms C (2016) Computer-based image analysis in breast pathology. J Pathol Inform 7:43

    Article  Google Scholar 

  8. Hamed G, El-Rahman Marey MA, El-Sayed Amin S, Tolba MF (2020) Deep learning in breast cancer detection and classification. In: Joint European-US Workshop on Applications of Invariance in Computer Vision, Springer, Cham, 322–333.

  9. https://www.dailyrounds.org/blog/breast-cancer-awareness-month-2020-a-wake-up-call-for-india/

  10. Shob K (2020) https://www.dailyrounds.org/blog/breast-cancer-awareness-month-2020-a-wake-up-call-forindia/

  11. Kumar A, Prateek M (2020) Localization of nuclei in breast Cancer using whole slide imaging system supported by morphological features and shape formulas. Cancer Manag Res 12:4573–4583

    Article  Google Scholar 

  12. Lobov SA, Mikhaylov AN, Shamshin M, Makarov VA, Kazantsev VB (2020) Spatial properties of STDP in a self-learning spiking neural network enable controlling a mobile robot. Front Neurosci 14:88

    Article  Google Scholar 

  13. Maurya AP, Brahmachari S (2021) Current status of breast cancer management in India. Indian J Surg 83:316–321

  14. Ray R, Abdullah AA, Mallick DK, Dash SR (2019) Classification of benign and malignant breast cancer using supervised machine learning algorithms based on image and numeric datasets. J Phys Conf Ser, IOP publishing 1372(1):012062

    Article  Google Scholar 

  15. Romano AM, Hernandez AA (2019) Enhanced deep learning approach for predicting invasive ductal carcinoma from histopathology images. In: 2019 2nd international conference on artificial intelligence and big data (ICAIBD), IEEE, 142-148.

  16. Roy S, Kumar R, Mittal V, Gupta D (2020) Classification models for invasive ductal carcinoma progression, based on gene expression data-trained supervised machine learning. Sci Rep 10(1):1–15

    Article  Google Scholar 

  17. Shaikh K, Krishnan S, Thanki R (2020) Artificial intelligence in breast Cancer early detection and diagnosis. Springer

  18. Shen L, Margolies LR, Rothstein JH, Fluder E, McBride R, Sieh W (2019) Deep learning to improve breast cancer detection on screening mammography. Sci Rep 9(1):1–12

    Google Scholar 

  19. Shi Y, Wei Z, Ling H, Wang Z, Shen J, Li P (2020) Person retrieval in surveillance videos via deep attribute mining and reasoning. IEEE Trans Multimedia 23:4376–4387

    Article  Google Scholar 

  20. Spanhol FA, Oliveira LS, Petitjean C, Heutte L (2015) A dataset for breast cancer histopathological image classification. IEEE Trans Biomed Eng 63(7):1455–1462

    Article  Google Scholar 

  21. Sun Y, Xu Z, Strell C, Moro CF, Wärnberg F, Dong L, Zhang Q (2018) Detection of breast tumour tissue regions in histopathological images using convolutional neural networks. In: 2018 IEEE international conference on image processing, applications and systems (IPAS), 98-103.

  22. Tiwari M, Bharuka R, Shah P, Lokare R (2020) Breast Cancer prediction using deep learning and machine learning techniques. Available at SSRN 3558786.

  23. Wang L, Qian X, Zhang Y, Shen J, Cao X (2019) Enhancing sketch-based image retrieval by cnn semantic re-ranking. IEEE Trans Cybern 50(7):3330–3342

    Article  Google Scholar 

  24. Yang S, Wang J, Deng B, Liu C, Li H, Fietkiewicz C, Loparo KA (2018) Real-time neuromorphic system for large-scale conductance-based spiking neural networks. IEEE Trans Cybern 49(7):2490–2503

    Article  Google Scholar 

  25. Yang S, Deng B, Wang J, Li H, Lu M, Che Y, Wei X, Loparo KA (2019) Scalable digital neuromorphic architecture for large-scale biophysically meaningful neural network with multi-compartment neurons. IEEE Trans Neural Netw Learn Syst 31(1):148–162

    Article  Google Scholar 

  26. Yang S, Gao T, Wang J, Deng B, Lansdell B, Linares-Barranco B (2021) Efficient spike-driven learning with dendritic event-based processing. Front Neurosci 15:97

    Google Scholar 

  27. Yang S, Wang J, Zhang N, Deng B, Pang Y, Azghadi MR (2021) CerebelluMorphic: large-scale neuromorphic model and architecture for supervised motor learning. IEEE Trans Neural Netw Learn Syst

  28. Yang S, Wang J, Hao X, Li H, Wei X, Deng B, Loparo KA (2021) BiCoSS: toward large-scale cognition brain with multigranular neuromorphic architecture. IEEE Trans Neural Netw Learn Syst

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Acknowledgements

I sincerely thanks S. Senthil for their guidance and encouragement in carrying out this research work.

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Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

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Correspondence to B. G. Deepa.

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Deepa, B.G., Senthil, S. Predicting invasive ductal carcinoma tissues in whole slide images of breast Cancer by using convolutional neural network model and multiple classifiers. Multimed Tools Appl 81, 8575–8596 (2022). https://doi.org/10.1007/s11042-022-12114-9

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  • DOI: https://doi.org/10.1007/s11042-022-12114-9

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