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Prostate cancer detection with an improved resonance sensor system: parameter evaluation in a silicone model and on human prostate tissue in vitro

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Abstract

The purpose of this study was to improve a resonance sensor system for prostate cancer detection and evaluate its performance on silicone with different hardness. Furthermore, to investigate if the instrument could distinguish between cancerous and normal prostate tissue in one in vitro prostate specimen. The system could measure the frequency shift, impression depth and the rise time of the force signal. The frequency shift, impression depth and the rise time described the relative hardness of silicone (n = 50, P < 0.05). The results from measurements on the prostate specimen indicated that there is a significant difference in the parameter data between cancerous and normal prostate tissue (n = 15, P < 0.05). The parameters’ impression depth and force rise time adds important information for cancer detection. Further studies on prostate tissue with different tumour types must be performed in order to understand the full value of the new sensor system.

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Abbreviations

Δf:

Frequency shift (kHz)

T R :

Rise time (s)

l p :

Impression depth (mm)

Q cancer :

Percentage of cancerous tissue

k x :

Stiffness

DAQ:

Data acquisition card

DRE:

Digital rectal palpation

PSA:

Prostate specific antigen

TRUS:

Transrectal ultrasound

TST:

Tactile sensor technology

fPLL:

Frequency-phase-locked loop

pPLL:

Position-phase-locked loop

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Acknowledgment

The study was supported by EU Objective One, northern Sweden, and the Swedish Cancer Society (project 4716).

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Authors and Affiliations

  1. Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden

    Peter Lindberg, Britt Andersson & Olof Lindahl

  2. Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden

    Anders Bergh

  3. Department of Surgical and Perioperative Science, Urology and Andrology, Umeå University, Umeå, Sweden

    Börje Ljungberg

  4. Centre for Biomedical Engineering and Physics, Umeå University, Umeå, Sweden

    Peter Lindberg, Britt Andersson & Olof Lindahl

Authors
  1. Peter Lindberg
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  2. Britt Andersson
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  3. Anders Bergh
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  4. Börje Ljungberg
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  5. Olof Lindahl
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Correspondence to Peter Lindberg.

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Lindberg, P., Andersson, B., Bergh, A. et al. Prostate cancer detection with an improved resonance sensor system: parameter evaluation in a silicone model and on human prostate tissue in vitro. Med Bio Eng Comput 44, 1053–1059 (2006). https://doi.org/10.1007/s11517-006-0129-y

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  • DOI: https://doi.org/10.1007/s11517-006-0129-y

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