Abstract
Controlled distension of hollow organs is an accepted technique for generating reproducible visceral stimuli. We have constructed a new, flexible and intelligent distension system in which discomfort, pain and autonomic responses are recorded online. These responses can be fed back into the system in a regulatory loop and be used to shape the distension paradigm. Consequently, it is possible to take all subjects to a state of equal, although subjective, level of discomfort or pain, even though pressure, tension and volume might be totally different. By using a variable airflow, this new distension system can be effectively used in all kinds of paradigms, e.g. phasic, tonic, or ramp distensions or customized combinations of them. The system can be used to control pressure, volume or tension. A refinement of the system is that it is possible to automatically change the controlled entity during a distension, e.g. from an isobaric ramp directly into an isovolumetric tonic phase. Furthermore, the distension device allows double distensions with independent distension paradigms.
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References
Anderson RH, Ness TJ, Gebhart GF (1987) A distension control device useful for quantitative studies of hollow organ sensation. Physiol Behav 41:635–638
Azpiroz F, Malagelada JR (1985) Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol Gastrointest Liver Physiol 248:G229–237
Bayati A, Karpefors M, Jerndal P et al (2006) Is there any correlation between viscero-motor response and sensation in man? Gastroenterology, DDW abstract (in press)
Bradette M, Delvaux M, Staumont G et al (1994) Evaluation of colonic sensory thresholds in IBS patients using a barostat. Dig Dis Sci 39:449–457
Distrutti E, Azpiroz F, Soldevilla A et al (1999) Gastric wall tension determines perception of gastric distension. Gastroenterology 116:1042
Hachet T, Caussette M (1993) A multifunction and programmable computerized barostat. Gastroenterol Clin Biol 17:347–351
Mertz H, Naliboff B, Munakata J et al (1995) Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 109:40–52
Munakata J, Naliboff B, Harraf F et al (1997) Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 112:55–63
Ng C, Malcolm A, Hansen R et al (2006) Distension technique influences the relationship between colonic and rectal hypersensitivity in irritable bowel syndrome. Neurogastroenterol Motil 18:206–210
Petersen P, Gao C, Arendt-Nielsen L et al (2003) Pain intensity and biomechanical responses during ramp-controlled distension of the human rectum. Dig Dis Sci 48:1316
Schmulson M, Chang L, Naliboff B et al (2000) Correlation of symptom criteria with perception thresholds during rectosigmoid distension in irritable bowel syndrome patients. Am J Gastroenterol 95:152–156
Toma TP, Zighelboim J, Phillips SF et al (1996) Methods for studying intestinal sensitivity and compliance: in vitro studies of balloons and a barostat. Neurogastroenterol Motil 8:19–28
Whitehead WE, Delvaux M (1997) Standardization of Barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. Dig Dis Sci 42:223–241
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Karpefors, M., Akkermans, L.M.A. & Bayati, A. A new intelligent distension system for hollow organs. Med Bio Eng Comput 45, 275–281 (2007). https://doi.org/10.1007/s11517-006-0154-x
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DOI: https://doi.org/10.1007/s11517-006-0154-x