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Diagnostic potential in state space parameters of lung sounds

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Abstract

The goal of this study was to investigate state space parameters of the lung sounds of healthy subjects and subjects with symptoms of asthma under different respiratory conditions. Our main objective was to elucidate the diagnostic potential of these parameters, which included embedding dimension (m), time delay (τ) and Lyapunov exponents (λ). Lung sounds were acquired over the right lower lobe from six healthy subjects, ages 10–26 years, and from eight children with symptoms of asthma recorded pre- and post-bronchial provocation via methacholine challenge (MCh) and post-bronchial dilation (BD). Inspiratory air flows during recordings were 7.5, 15, or 22.5 mL/s per kg (±20%). With increasing flow for sounds recorded from healthy subjects, mean values of τ decreased. Percent of breaths with positive λ decreased when heart sounds were excluded. For the patients who exhibited bronchoconstriction, values of τ increased and percent of positive λ decreased post-MCh, and returned to pre-MCh values post-BD. Thus, both τ and presence of positive λ may prove valuable in developing a model that will predict changes in respiratory status using lung sounds.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Manitoba, R3T 5V6, Winnipeg, MB, Canada

    January Gnitecki & Zahra Moussavi

  2. Department of Pediatrics and Child Health, University of Manitoba and Manitoba Institute of Child Health, R3E 3PA, Winnipeg, MB, Canada

    Hans Pasterkamp

Authors
  1. January Gnitecki
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  2. Zahra Moussavi
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  3. Hans Pasterkamp
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Corresponding author

Correspondence to Zahra Moussavi.

Additional information

This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Manitoba Institute of Child Health.

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Gnitecki, J., Moussavi, Z. & Pasterkamp, H. Diagnostic potential in state space parameters of lung sounds. Med Bio Eng Comput 46, 93–99 (2008). https://doi.org/10.1007/s11517-007-0270-2

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