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Use of sensitive devices to assess the effect of medication on attentional demands of precision and power grips in individuals with Parkinson disease

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Abstract

Deficits in fine motor control are a common early symptom in people with Parkinson disease (PD) and may serve as an ideal marker for the response to therapeutic interventions and progression of the disease. The long-term goal of this research is to develop sensitive clinical markers that can be used to accurately assess disease progression and the response to therapeutic interventions. The purpose of this preliminary study was to examine the effects of medication on the attentional demands of precision (Pre) and power (Pow) grips in individuals with PD. In order to assess force control during precision and power grip, we used an instrumented twist-cap device. Performance on the motor task was quantified using peak force levels (PF) and the time to reach peak force (TTP). To assess attentional demands of the motor task, participants performed an auditory analog of the Stroop test while performing the motor task. Dual-task cost (DTC) for all outcome variables was calculated. Dual-task cost for response latency (RL DTC) for both grips were greater (P < 0.005) when participants were on medications(‘ONMeds’). Mean [95%CI]: Pre = 25.7[14.7–36.7], Pow = 37.08[26.5–47.7]) compared with off medications(‘OFFMeds’) (Pre = 12.6[1.5–23.6], Pow = 10.98[0.4–21.6]), suggesting that force control during both grip tasks may remain attentionally demanding even on medications.

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References

  1. Agostino R, Curra A, Giovannelli M, Modugno N, Manfredi M, Berardelli A (2003) Impairment of individual finger movements in Parkinson’s disease. Mov Disord 18:560–565

    Article  PubMed  Google Scholar 

  2. Berardelli A, Rothwell JC, Thompson PD, Hallett M (2001) Pathophysiology of bradykinesia in Parkinson’s disease. Brain 124:2131–2146

    Article  PubMed  CAS  Google Scholar 

  3. Berardelli A, Sabra AF, Hallett M (1983) Physiological mechanisms of rigidity in Parkinson’s disease. J Neurol Neurosurg Psychiatry 46:45–53

    Article  PubMed  CAS  Google Scholar 

  4. Brooks DJ, Frey KA, Marek KL, Oakes D, Paty D, Prentice R, Shults CW, Stoessl AJ (2003) Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson’s disease. Exp Neurol 184(1):S68–S79

    Article  PubMed  CAS  Google Scholar 

  5. Contreras-Vidal JL, Stelmach GE (1995) A neural model of basal ganglia-thalamocortical relations in normal and parkinsonian movement. Biol Cybern 73:467–476

    Article  PubMed  CAS  Google Scholar 

  6. Contreras-Vidal JL, Stelmach GE (1996) Effects of Parkinsonism on motor control. Life Sci 58:165–176

    Article  PubMed  CAS  Google Scholar 

  7. de Lau LM, Breteler MM (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535

    Article  PubMed  Google Scholar 

  8. Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM (2007) Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68:384–386

    Article  PubMed  CAS  Google Scholar 

  9. Fellows SJ, Noth J (2004) Grip force abnormalities in de novo Parkinson’s disease. Mov Disord 19:560–565

    Article  PubMed  Google Scholar 

  10. Fellows SJ, Noth J, Schwarz M (1998) Precision grip and Parkinson’s disease. Brain 121(9):1771–1784

    Article  PubMed  Google Scholar 

  11. Hochstadt J (2009) Set-shifting and the on-line processing of relative clauses in Parkinson’s disease: results from a novel eye-tracking method. Cortex 45:991–1011

    Article  PubMed  Google Scholar 

  12. McDonald C, Brown GG, Gorell JM (1996) Impaired set-shifting in Parkinson’s disease: new evidence from a lexical decision task. J Clin Exp Neuropsychol 18:793–809

    Article  PubMed  CAS  Google Scholar 

  13. Pirker W, Djamshidian S, Asenbaum S, Gerschlager W, Tribl G, Hoffmann M, Brucke T (2002) Progression of dopaminergic degeneration in Parkinson’s disease and atypical parkinsonism: a longitudinal beta-CIT SPECT study. Mov Disord 17:45–53

    Article  PubMed  Google Scholar 

  14. Richards M, Cote LJ, Stern Y (1993) Executive function in Parkinson’s disease: set-shifting or set-maintenance? J Clin Exp Neuropsychol 15:266–279

    Article  PubMed  CAS  Google Scholar 

  15. Rochester L, Burn DJ, Woods G, Godwin J, Nieuwboer A (2009) Does auditory rhythmical cueing improve gait in people with Parkinson’s disease and cognitive impairment? A feasibility study Mov Disord 24:839–845

    Google Scholar 

  16. Smaby NJM, Baker B, Kenney DE, Murray WM, Hentz VR (2004) Identification of key pinch forces required to complete functional tasks. J Rehabil Res Dev 41:215–224

    Article  PubMed  Google Scholar 

  17. Spielman J, Ramig LO, Mahler L, Halpern A, Gavin WJ (2007) Effects of an extended version of the lee silverman voice treatment on voice and speech in Parkinson’s disease. Am J Speech Lang Pathol 16:95–107

    Article  PubMed  Google Scholar 

  18. Uitti RJ, Baba Y, Wszolek ZK, Putzke DJ (2005) Defining the Parkinson’s disease phenotype: initial symptoms and baseline characteristics in a clinical cohort. Parkinsonism Relat Disord 11:139–145

    Article  PubMed  Google Scholar 

  19. Vaillancourt DE, Yu H, Mayka MA, Corcos DM (2007) Role of the basal ganglia and frontal cortex in selecting and producing internally guided force pulses. Neuroimage 36:793–803

    Article  PubMed  Google Scholar 

  20. Visser M, Marinus J, Stiggelbout AM, van Hilten JJ (2006) Responsiveness of impairments and disabilities in Parkinson’s disease. Parkinsonism Relat Disord 12:314–318

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work is supported by the University of Washington—Advanced Rehabilitation Research Training (NIDRR training grant number H133P080008).

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Correspondence to Sujata D. Pradhan.

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Pradhan, S.D., Scherer, R., Matsuoka, Y. et al. Use of sensitive devices to assess the effect of medication on attentional demands of precision and power grips in individuals with Parkinson disease. Med Biol Eng Comput 49, 1195–1199 (2011). https://doi.org/10.1007/s11517-011-0798-z

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  • DOI: https://doi.org/10.1007/s11517-011-0798-z

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