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Influence of the shape of intracellular potentials on the morphology of single-fiber extracellular potentials in human muscle fibers

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Abstract

Attention of the investigators is usually pointed to the peak-to-peak characteristics of single-fiber action potentials (SFAPs) that are mainly determined by the depolarizing phase of the intracellular action potential (IAP). However, the final portion of the SFAP has often specific shape that has to be related to peculiarities of the repolarization phase of IAP and the duration of its spike. A novel piecewise SFAP model is proposed to achieve greater insight into the nature of declining portion of the negative phase and of the third phase of SFAP. It was found that the SFAP third phase is essentially determined by the specific profile of the transition of the IAP falling phase toward the resting voltage, whereas the SFAP declining negative phase is more dependent upon the width of the corresponding IAP spike. We tentatively suggest that the duration of the spike of human IAPs should be over approximately 0.75 ms.

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Author notes

  1. Javier Rodriguez-Falces

    Present address: Universidad Pública de Navarra D.I.E.E, Campus de Arrosadía s/n, 31006, Pamplona, Spain

Authors and Affiliations

  1. Department of Electrical and Electronic Engineering, Public University of Navarra, 31006, Pamplona, Spain

    Javier Rodriguez-Falces, Javier Navallas & Armando Malanda

  2. Department of Clinical Neurophysiology, Virgen del Camino Hospital, 31008, Pamplona, Spain

    Luis Gila

  3. Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Nonna Alexandrovna Dimitrova

Authors
  1. Javier Rodriguez-Falces
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  2. Javier Navallas
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  3. Luis Gila
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  4. Armando Malanda
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  5. Nonna Alexandrovna Dimitrova
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Correspondence to Javier Rodriguez-Falces.

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Rodriguez-Falces, J., Navallas, J., Gila, L. et al. Influence of the shape of intracellular potentials on the morphology of single-fiber extracellular potentials in human muscle fibers. Med Biol Eng Comput 50, 447–460 (2012). https://doi.org/10.1007/s11517-012-0879-7

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  • DOI: https://doi.org/10.1007/s11517-012-0879-7

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