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Computer methods for follow-up study of hemodynamic and disease progression in the stented coronary artery by fusing IVUS and X-ray angiography

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Abstract

Despite a lot of progress in the fields of medical imaging and modeling, problem of estimating the risk of in-stent restenosis and monitoring the progress of the therapy following stenting still remains. The principal aim of this paper was to propose architecture and implementation details of state of the art of computer methods for a follow-up study of disease progression in coronary arteries stented with bare-metal stents. The 3D reconstruction of coronary arteries was performed by fusing X-ray angiography and intravascular ultrasound (IVUS) as the most dominant modalities in interventional cardiology. The finite element simulation of plaque progression was performed by coupling the flow equations with the reaction–diffusion equation applying realistic boundary conditions at the wall. The alignment of baseline and follow-up data was performed automatically by temporal alignment of IVUS electrocardiogram-gated frames. The assessment was performed using three six-month follow-ups of right coronary artery. Simulation results were compared with the ground truth data measured by clinicians. In all three data sets, simulation results indicated the right places as critical. With the obtained difference of 5.89 ± ~4.5 % between the clinical measurements and the results of computer simulations, we showed that presented framework is suitable for tracking the progress of coronary disease, especially for comparing face-to-face results and data of the same artery from distinct time periods.

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Acknowledgments

This study was funded by a grant from FP7-ICT-2007 project (grant agreement 224297, ARTreat) and grants from Serbian Ministry of Education and Science III41007 and ON174028. Also, we would like to thank three anonymous reviewers for very constructive suggestions which improved the present paper.

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Authors and Affiliations

  1. Faculty of Engineering, University of Kragujevac, Sestre Janjic 6, Kragujevac, 34000, Serbia

    Arso M. Vukicevic, Gordana R. Jovicic & Nenad D. Filipovic

  2. Faculty of Medicine, University of Nis, Nis, Serbia

    Nemanja M. Stepanovic & Svetlana R. Apostolovic

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  1. Arso M. Vukicevic
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  2. Nemanja M. Stepanovic
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Correspondence to Nenad D. Filipovic.

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Vukicevic, A.M., Stepanovic, N.M., Jovicic, G.R. et al. Computer methods for follow-up study of hemodynamic and disease progression in the stented coronary artery by fusing IVUS and X-ray angiography. Med Biol Eng Comput 52, 539–556 (2014). https://doi.org/10.1007/s11517-014-1155-9

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