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Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries

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Abstract

Prevention and early detection of atherosclerosis are critical for protection against subsequent circulatory disease. In this study, an automated two-dimensional ultrasonic-measurement-integrated (2D-UMI) blood flow analysis system for clinical diagnosis was developed, and the feasibility of the system for hemodynamic analysis in a carotid artery was revealed. The system automatically generated a 2D computational domain based on ultrasound color Doppler imaging and performed a UMI simulation of blood flow field to visualize hemodynamics in the domain. In the UMI simulation, compensation of errors was applied by adding feedback signals proportional to the differences between Doppler velocities by measurement and computation while automatically estimating the cross-sectional average inflow velocity. The necessity of adjustment of the feedback gain was examined by analyzing blood flow in five carotid arteries: three healthy, one sclerosed, and one stenosed. The same feedback gain was generally applicable for the 2D-UMI simulation in all carotid arteries, depending on target variables. Thus, the present system was shown to be versatile in the sense that the parameter is patient independent. Moreover, the possibility of a new diagnostic method based on the hemodynamic information obtained by the 2D-UMI simulation, such as a waveform of the cross-sectional average inflow velocity and wall shear stress distributions, was suggested.

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Acknowledgments

Part of this study was supported by Grant-in-Aid for Scientific Research (B) (24360064). All computations were performed using the supercomputer system at the Advanced Fluid Information (AFI) Research Center, Institute of Fluid Science, Tohoku University.

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Authors and Affiliations

  1. Graduate School of Biomedical Engineering, Tohoku University, Sendai, 980-8579, Japan

    Takaumi Kato & Shusaku Sone

  2. Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan

    Kenichi Funamoto & Toshiyuki Hayase

  3. Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan

    Hiroko Kadowaki

  4. GE Healthcare Japan, Hino, 191-8503, Japan

    Tadashi Shimazaki, Takao Jibiki, Koji Miyama & Lei Liu

Authors
  1. Takaumi Kato
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  2. Kenichi Funamoto
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  3. Toshiyuki Hayase
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  4. Shusaku Sone
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  5. Hiroko Kadowaki
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  6. Tadashi Shimazaki
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  7. Takao Jibiki
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  8. Koji Miyama
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  9. Lei Liu
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Correspondence to Kenichi Funamoto.

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Kato, T., Funamoto, K., Hayase, T. et al. Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries. Med Biol Eng Comput 52, 933–943 (2014). https://doi.org/10.1007/s11517-014-1193-3

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  • DOI: https://doi.org/10.1007/s11517-014-1193-3

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