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Evaluation of an Expanded Disability Status Scale (EDSS) modeling strategy in multiple sclerosis

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Abstract

The Expanded Disability Status Scale (EDSS) is the most widely used scale to evaluate the degree of neurological impairment in multiple sclerosis (MS). In this paper, we report on the evaluation of an EDSS modeling strategy based on recurrence quantification analysis (RQA) of posturographic data (i.e., center of pressure, COP). A total of 133 volunteers with EDSS ranging from 0 to 4.5 participated in this study, with eyes closed. After selection of time delay (τ), embedding dimension (m) as well as threshold (radius, r) to identify recurrent points, several RQA measures were calculated for each COP’s position and velocity data in the mono- and multi-dimensional RQAs. Estimation results lead to the selection of the recurrence rate (RR) of the COP’s position as the most pertinent RQA measure. The performance of the models versus raw and noisy data was higher in the mono-dimensional analysis than in the multi-dimensional. This study suggests that the posturographic signal’s mono-dimensional RQA is a more pertinent method to quantify disability in MS than the multi-dimensional RQA.

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Acknowledgments

The authors wish to thank the Saint Philibert Hospital, Lomme, for providing posturographic data of healthy subjects and patients with multiple sclerosis.

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Authors and Affiliations

  1. Department of Energy, Electricity and Automatic, HEI, 13 rue de Toul, 59046, Lille, France

    Hua Cao & Laurent Peyrodie

  2. Biomedical Signal Processing Unit, Catholic University of Lille, Lille, France

    Hua Cao, Laurent Peyrodie, Olivier Agnani & Fabrice Cavillon

  3. Department of Physical Medicine and Rehabilitation, Groupe Hospitalier de l’Institut Catholique de Lille (GHICL), Lille, France

    Olivier Agnani & Cécile Donzé

  4. Faculté de Médecine et de Maïeutique, Lille, France

    Fabrice Cavillon & Patrick Hautecoeur

  5. Department of Neurology, Groupe Hospitalier de l’Institut Catholique de Lille (GHICL), Lille, France

    Patrick Hautecoeur

Authors
  1. Hua Cao
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  2. Laurent Peyrodie
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  3. Olivier Agnani
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  4. Fabrice Cavillon
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  5. Patrick Hautecoeur
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  6. Cécile Donzé
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Correspondence to Hua Cao.

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Cao, H., Peyrodie, L., Agnani, O. et al. Evaluation of an Expanded Disability Status Scale (EDSS) modeling strategy in multiple sclerosis. Med Biol Eng Comput 53, 1141–1151 (2015). https://doi.org/10.1007/s11517-015-1383-7

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  • DOI: https://doi.org/10.1007/s11517-015-1383-7

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