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The numerical study on specialized treatment strategies of enhanced external counterpulsation for cardiovascular and cerebrovascular disease

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Abstract

Traditional clinical mode of enhanced external counterpulsation is not targeted for different diseases. Specialized strategies in the treatment of enhanced external counterpulsation for coronary heart disease and cerebral ischemic stroke are supposed to be distinguished. The goal of treatment for coronary heart disease is diastolic blood pressure/systolic blood pressure = Q ≥ 1.2 after counterpulsation, while the goal of treatment for cerebral ischemic stroke is the improvement of mean arterial pressure. A computational lumped parameter model was established for the simulation of hemodynamic effect of enhanced external counterpulsation on two diseases. Vessel collapse was considered during the simulation of counterpulsation. Based on different pressurized and decompressed rate, pressurized moment, pressure duration, and pressure amplitude, different counterpulsation modes were applied to the model and the immediate hemodynamic effects were compared. Results showed that the pressure duration and pressure amplitude had most influence on two diseases. For cerebral ischemic stroke, the longer pressure duration and the higher pressure amplitude of thighs, the higher mean arterial pressure; while for coronary heart disease, the value of Q was highest when the pressure end moment was 0.6 s during a 0.88-s cardiac cycle, and Q had a linear increase in the pressure amplitude of buttocks, but little change with the increase of calves and thighs pressure amplitude. For patients with coronary heart disease, the pressure duration was not supposed to be too long to avoid the increase of systolic blood pressure, and the improvement of pressure amplitude of buttocks could promise a positive treatment effect for coronary heart disease. While for patients with cerebral ischemic stroke, both the long pressure duration of each part and the high pressure amplitude of thighs could result in the systolic blood pressure and diastolic blood pressure have a certain increase, thus promoting the maximum mean arterial pressure and a best treatment.

The specialized treatment strategies of EECP for cardiovascular and cerebrovascular disease

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Funding

This study was supported by the National Natural Science Foundation of China (11772016, 11472022) and Key Project of Science and Technology of Beijing Municipal Education Commission.

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Authors and Affiliations

  1. College of Life Science and Bioengineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, People’s Republic of China

    Bao Li, Sihan Chen, Xingming Qi, Wenxin Wang, Boyan Mao & Youjun Liu

  2. The Eighth Affiliated Hospital, Sun Yat-sen University, No. 3025 ShenNan Road, Shenzhen, 518033, Guangdong, China

    Jianhang Du & Xiaoling Li

Authors
  1. Bao Li
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  2. Sihan Chen
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  3. Xingming Qi
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  4. Wenxin Wang
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  5. Boyan Mao
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  6. Jianhang Du
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  7. Xiaoling Li
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  8. Youjun Liu
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Correspondence to Youjun Liu.

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Li, B., Chen, S., Qi, X. et al. The numerical study on specialized treatment strategies of enhanced external counterpulsation for cardiovascular and cerebrovascular disease. Med Biol Eng Comput 56, 1959–1971 (2018). https://doi.org/10.1007/s11517-018-1834-z

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  • DOI: https://doi.org/10.1007/s11517-018-1834-z

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