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Prediction of glandularity and breast radiation dose from mammography results in Japanese women

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Abstract

Glandularity has a marked impact on the incidence of breast cancer and the missed lesion rate of mammography. The aim of this study was to develop a novel model for predicting glandularity and patient radiation dose using physical factors that are easily determined prior to mammography. Data regarding glandularity and mean glandular dose were obtained from 331 mammograms. A stepwise multiple regression analysis model was developed to predict glandularity using age, compressed breast thickness and body mass index (BMI), while a model to predict mean glandular dose was created using quantified glandularity, age, compressed breast thickness, height and body weight. The most significant factor for predicting glandularity was age, the influence of which was 1.8 times that of BMI. The most significant factor for predicting mean glandular dose was compressed breast thickness, the influence of which was 1.4 times that of glandularity, 3.5 times that of age and 6.1 times that of height. Both models were statistically significant (both p < 0.0001). Easily determined physical factors were able to explain 42.8% of the total variance in glandularity and 62.4% of the variance in mean glandular dose.

Validation results of the above prediction model made using physical factors in Japanese women. The plotted points of actual vs. prediction glandularity shown in a are distributed in the vicinity of the diagonal line, and the residual plot for predicted glandularity shows an almost random distribution as shown in b. These distributions indicate the appropriateness of the prediction model.

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Funding

This work was supported by JSPS Grants-in-Aid Scientific Research, Grant Number JP18K07736.

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Authors and Affiliations

  1. Department of Central Radiology, Kindai University Hospital, 377-2, Osaka-sayama, Osaka, 589-8511, Japan

    Mika Yamamuro, Yoshiyuki Asai & Koji Yamada

  2. Kyoto Prefectural Police Headquarters, Research Institute of Scientific Investigation, Kyoto, 602-8550, Japan

    Yoshiaki Ozaki

  3. Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan

    Masao Matsumoto

  4. Department of Radiology, School of Medicine, Kobe University, Kobe, Hyogo, 650-0017, Japan

    Takamichi Murakami

Authors
  1. Mika Yamamuro
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  2. Yoshiyuki Asai
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  4. Yoshiaki Ozaki
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  5. Masao Matsumoto
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  6. Takamichi Murakami
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Correspondence to Yoshiyuki Asai.

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This study was approved by the ethics committee of Kindai University, Japan, and all work was conducted in accordance with the World Medical Association Declaration of Helsinki.

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Yamamuro, M., Asai, Y., Yamada, K. et al. Prediction of glandularity and breast radiation dose from mammography results in Japanese women. Med Biol Eng Comput 57, 289–298 (2019). https://doi.org/10.1007/s11517-018-1882-4

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  • DOI: https://doi.org/10.1007/s11517-018-1882-4

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