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Sensitivity analysis of fiducial placement on transorbital target registration error

  • Original Article
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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Objective

In many clinical applications of image-guided surgery, skin fiducial placement is poorly defined and occasionally poorly executed, leading to an increase in the target registration error (TRE). Fiducial placement analysis usually focuses on a single target, where surgical guidance requires accurate localization of a region or volume of tissue. To address these limitations, a method of fiducial positioning for minimizing the TRE in a target region was developed.

Method

This methodology uses patient specific anatomic data, the patient skin surface and accounts for areas which may be poor choices for fiducial placement due to likely fiducial motion. The effect of skin motion on the expected TRE of a target region was modeled and evaluated. Transorbital therapy delivery was selected as the application of interest, so facial morphology is of greatest importance. Our target region is the pyramidal space behind the globe of the eye. A laser range scan of the face of a skull phantom with taboo regions chosen semiautomatically was used as an input to the simulated annealing optimization algorithm.

Results

Optimizing the fiducial position reduced the expected TRE by 50% when compared to an unoptimized fiducial placement. In addition, the effect of fiducial motion or localizer fiducial localization error is also reduced in the optimized version.

Conclusion

Improved registration results for transorbital therapy delivery were achieved semiautomatically using optical facial surface scans for image-guided surgical localization. The target registration error minimization method was feasible for in vivo applications.

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

    Nkiruka C. Atuegwu & Robert L. Galloway

  2. Department of Surgery, Vanderbilt University, Nashville, TN, USA

    Robert L. Galloway

  3. Department of Neurological Surgery, Vanderbilt University, Nashville, TN, USA

    Robert L. Galloway

Authors
  1. Nkiruka C. Atuegwu
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  2. Robert L. Galloway
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Correspondence to Nkiruka C. Atuegwu.

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Atuegwu, N.C., Galloway, R.L. Sensitivity analysis of fiducial placement on transorbital target registration error. Int J CARS 2, 397–404 (2008). https://doi.org/10.1007/s11548-008-0150-8

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  • DOI: https://doi.org/10.1007/s11548-008-0150-8

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