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Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Radio-frequency (RF) has been used to induce ablation and coagulation in liver for minimizing blood loss during liver resection. A multi-level tissue model that we have developed to investigate the changes in electrical properties of liver tissue during RF ablation.

Methods

The proposed computational model comprises of an equivalent circuit consisting of resistors and capacitors. The potential difference across the cells and the extracellular structure is used to help predicting the associated changes in tissue electrical property. Experiments were done to validate the proposed model and computer simulation.

Results

The changes in tissue mechanical properties were correlated with that of electrical property using experiments.

Conclusion

Knowledge of tissue properties changes in associated with changes at the cells and the extracellular structure can be used to optimize RF ablation and tissue division during surgery.

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Authors and Affiliations

  1. Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore

    Wei-Hsuan Huang, Chee-Kong Chui & Swee-Hin Teoh

  2. Department of Precision Engineering, The University of Tokyo, Tokyo, Japan

    Etsuko Kobayashi

  3. Department of Surgery, National University Hospital, Singapore, Singapore

    Stephen Chang

Authors
  1. Wei-Hsuan Huang
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  2. Chee-Kong Chui
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  3. Etsuko Kobayashi
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  4. Swee-Hin Teoh
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  5. Stephen Chang
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Corresponding author

Correspondence to Wei-Hsuan Huang.

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Huang, WH., Chui, CK., Kobayashi, E. et al. Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation. Int J CARS 6, 601–607 (2011). https://doi.org/10.1007/s11548-010-0537-1

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  • DOI: https://doi.org/10.1007/s11548-010-0537-1

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