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MRI-compatible positioning device for guiding a focused ultrasound system for transrectal treatment of prostate cancer

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Background   

High-intensity focused ultrasound (HIFU) is a promising treatment method for many common cancers, including prostate cancer. Magnetic resonance image (MRI) guidance of HIFU permits targeting and monitoring of therapy. A prototype MRI-compatible positioning device that navigates a HIFU transducer was designed, fabricated and tested.

Materials and methods   

The positioning device has two PC-controlled and one manually driven stage that allow endorectal access to the prostate. The positioning device was constructed using a 3-D rapid prototype manufacturing device. Software was developed that controls the motion of the positioning device and enables activation of a HIFU transducer. In vitro testing of the system was performed in a 1.5T MRI scanner using ex vivo turkey tissue. Optical encoders were employed to enhance the accuracy of this positioning device.

Result   

The positioning device was successfully tested for MRI compatibility. The movement error of the positioning device is approximately 20 \(\upmu \)m. The robot has the ability to accurately move the transducer for creation of discrete and overlapping lesions.

Conclusion   

An MRI-compatible HIFU positioning system was developed that has the ability to create thermal lesions with MRI guidance for endorectal treatment of prostate cancer.

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Acknowledgments

This work was supported by the Project PROFUS E! 6620. PROFUS is implemented within the framework of the EUROSTARS Program and is co-funded by the European Community and the Research Promotion Foundation, under the EUROSTARS Cyprus Action of the EUREKA Cyprus Program (Project Code: EUREKA/EUSTAR/0311/01).

Conflict of interest

Christos Yiallouras, Nicos Mylonas, and Christakis Damianou declare that they have no conflict of interest. Ethical standards  All animal studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All institutional and national guidelines for the care and use of laboratory animals were followed.

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Authors and Affiliations

  1. MEDSONIC LTD, Limassol, Cyprus

    Christos Yiallouras & Christakis Damianou

  2. City University, London, UK

    Christos Yiallouras

  3. Frederick University Cyprus, Limassol, Cyprus

    Nicos Mylonas

  4. Cyprus University of Technology, Limassol, Cyprus

    Christakis Damianou

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  1. Christos Yiallouras
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  2. Nicos Mylonas
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Correspondence to Christakis Damianou.

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Yiallouras, C., Mylonas, N. & Damianou, C. MRI-compatible positioning device for guiding a focused ultrasound system for transrectal treatment of prostate cancer. Int J CARS 9, 745–753 (2014). https://doi.org/10.1007/s11548-013-0964-x

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  • DOI: https://doi.org/10.1007/s11548-013-0964-x

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