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Experimental investigation of intravascular OCT for imaging of intracranial aneurysms

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Rupture risk assessment of an intracranial aneurysm (IA) is an important factor for indication of therapy. Until today, there is no suitable objective prediction method. Conventional imaging modalities cannot assess the IA’s vessel wall. We investigated the ability of intravascular optical coherence tomography (OCT) as a new tool for the characterization and evaluation of IAs.

Materials and methods

An experimental setup for acquisition of geometrical aneurysm parameters was developed. Object of basic investigation was a silicone phantom with six IAs from patient data. For structural information, three circle of Willis were dissected and imaged postmortem. All image data were postprocessed by medical imaging software.

Results

Geometrical image data of a phantom with six different IAs were acquired. The geometrical image data showed a signal loss, e.g., in aneurysms with a high bottleneck ratio. Imaging data of vessel specimens were evaluated with respect to structural information that is valuable for the characterization of IAs. Those included thin structures (intimal flaps), changes of the vessel wall morphology (intimal thickening, layers), adjacent vessels, small vessel outlets, arterial branches and histological information.

Conclusion

Intravascular OCT provides new possibilities for diagnosis and rupture assessment of IAs. However, currently used imaging system parameters have to be adapted and new catheter techniques have to be developed for a complete assessment of the morphology of IAs.

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References

  1. Forsting M, Wanke I (2008) Intracranial vascular malformations and aneurysms. Springer, Berlin

    Book  Google Scholar 

  2. Keedy A (2006) An overview of intracranial aneurysms. McGill J Med 9(2):141

    PubMed Central  PubMed  Google Scholar 

  3. Mueller OM, Schlamann M, Mueller D, Sandalcioglu IE, Forsting M, Sure U (2011) Intracranial aneurysms: optimized diagnostic tools call for thorough interdisciplinary treatment strategies. Therapeutic advances in neurological disorders, pp. 1756285611415309

  4. Vernooij MW, Ikram MA, Tanghe HL, Vincent Arnaud JPE, Hofman A, Krestin GP, Niessen WJ, Breteler Monique MB, van der Lugt A (2007) Incidental findings on brain MRI in the general population. N Engl J Med 357(18):1821–1828

    Article  CAS  PubMed  Google Scholar 

  5. Wiebers DO (2003) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362(9378):103–110

    Article  PubMed  Google Scholar 

  6. Tearney GJ, Jang I-K, Bouma BE (2006) Optical coherence tomography for imaging the vulnerable plaque. J Biomed Opt 11(2):021002-021002-10

    Article  Google Scholar 

  7. Prati F, Regar E, Mintz GS, Arbustini E, Di Mario C, Jang I-K, Akasaka T, Costa M, Guagliumi G, Grube E (2010) Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J 31(4):401–415

    Article  PubMed  Google Scholar 

  8. Murata A, Wallace-Bradley D, Tellez A, Alviar C, Aboodi M, Sheehy A, Coleman L, Perkins L, Nakazawa G, Mintz G (2010) Accuracy of optical coherence tomography in the evaluation of neointimal coverage after stent implantation. JACC Cardiovasc Imaging 3(1):76–84

    Article  PubMed  Google Scholar 

  9. Kang S-J, Mintz GS, Akasaka T, Park D-W, Lee J-Y, Kim W-J, Lee S-W, Kim Y-H, Lee CW, Park S-W (2011) Optical coherence tomographic analysis of in-stent neoatherosclerosis after drug-eluting stent implantation. Circulation 123(25):2954–2963

    Article  CAS  PubMed  Google Scholar 

  10. Farooq MU, Khasnis A, Majid A, Kassab MY (2009) The role of optical coherence tomography in vascular medicine. Vasc Med 14(1):63–71

    Article  PubMed  Google Scholar 

  11. Standish BA, Spears J, Marotta TR, Montanera W, Yang VX (2012) Vascular wall Imaging of vulnerable atherosclerotic carotid plaques: current state of the art and potential future of endovascular optical coherence tomography. Am J Neuroradiol 33(9):1642–1650

    Article  CAS  PubMed  Google Scholar 

  12. Fujimoto JG, Pitris C, Boppart SA, Brezinski ME (2000) Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia 2(1):9–25

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Smith AM, Mancini MC, Nie S (2009) Bioimaging: second window for in vivo imaging. Nat Nanotechnol 4(11):710–711

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Frösen J, Tulamo R, Paetau A, Laaksamo E, Korja M, Laakso A, Niemelä M, Hernesniemi J (2012) Saccular intracranial aneurysm: pathology and mechanisms, (eng). Acta Neuropathol 123(6):773–786

    Article  PubMed  Google Scholar 

  15. Thorell WE, Chow MM, Prayson RA, Shure MA, Jeon SW, Huang D, Zeynalov E, Woo HH, Rasmussen PA, Rollins AM (2005) Optical coherence tomography: a new method to assess aneurysm healing. J Neurosurg 102(2):348

    Article  PubMed Central  PubMed  Google Scholar 

  16. Mathews MS, Su J, Heidari E, Levy EI, Linskey ME, Chen Z (2011) Neuroendovascular optical coherence tomography imaging and histological analysis. Neurosurgery 69(2):430

    Article  PubMed Central  PubMed  Google Scholar 

  17. Mathews MS, Su J, Heidari E, Linskey ME, Chen Z (eds) (2011) Neuro-endovascular optical coherence tomography imaging: clinical feasibility and applications. SPIE BiOS. International Society for Optics and Photonics, pp 788341-1–788341-7

  18. Lopes DK, Johnson AK (2011) Evaluation of cerebral artery perforators and the pipeline embolization device using optical coherence tomography. J Neurointerv Surg neurintsurg-2011-010102

  19. van der Marel K, Gounis M, King R, Wakhloo A, Puri A (2014) P-001 high-resolution optical and angiographic CT imaging of flow-diverter stents for assessment of vessel wall apposition, (eng). J Neurointerv Surg 6(Suppl 1):A21

    Article  Google Scholar 

  20. Costalat V, Sanchez M, Ambard D, Thines L, Lonjon N, Nicoud F, Brunel H, Lejeune JP, Dufour H, Bouillot P (2011) Biomechanical wall properties of human intracranial aneurysms resected following surgical clipping (IRRAs Project). J Biomech 44(15):2685–2691

    Article  CAS  PubMed  Google Scholar 

  21. Sun C, Standish B, Yang VXD (2011) Optical coherence elastography: current status and future applications. J Biomed Opt 16(4):043001-043001-12

    Article  Google Scholar 

  22. Lall RR, Eddleman CS, Bendok BR, Batjer HH (2009) Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: sifting through the sands of data. Neurosurg Focus 26(5):E2

    Article  PubMed  Google Scholar 

  23. Kleinloog R, Korkmaz E, Zwanenburg JJ, Kuijf HJ, Visser F, Blankena R, Post JA, Ruigrok YM, Luijten PR, Regli L, Rinkel GJ, Verweij BH (2014) Visualization of the aneurysm wall: a 7.0-tesla magnetic resonance imaging study. Neurosurgery 75(6):614–622

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was partly funded by the Federal Ministry of Education and Research (BMBF) and Saxony-Anhalt within the Forschungscampus STIMULATE (13GW0095A; I60).

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Authors and Affiliations

  1. Institute of Neuroradiology, Otto-von-Guericke University, Magdeburg, Germany

    Thomas Hoffmann, Oliver Beuing & Martin Skalej

  2. Department of Simulation and Graphics, Otto-von-Guericke University, Magdeburg, Germany

    Sylvia Glaßer

  3. Department of Medical Engineering, Otto-von-Guericke University, Magdeburg, Germany

    Axel Boese

  4. Institute of Forensic Medicine, Otto-von-Guericke University, Magdeburg, Germany

    Knut Brandstädter

  5. Institute of Pathology, Otto-von-Guericke University, Magdeburg, Germany

    Thomas Kalinski

Authors
  1. Thomas Hoffmann
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  2. Sylvia Glaßer
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  3. Axel Boese
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  4. Knut Brandstädter
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  5. Thomas Kalinski
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  6. Oliver Beuing
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  7. Martin Skalej
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Corresponding author

Correspondence to Thomas Hoffmann.

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There is no conflict of interest in this study.

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Hoffmann, T., Glaßer, S., Boese, A. et al. Experimental investigation of intravascular OCT for imaging of intracranial aneurysms. Int J CARS 11, 231–241 (2016). https://doi.org/10.1007/s11548-015-1275-1

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  • DOI: https://doi.org/10.1007/s11548-015-1275-1

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