Abstract
Purpose
In our previous study, we developed a computer-aided diagnosis (CADx) system using imaging findings annotated by radiologists. The system, however, requires radiologists to input many imaging findings. In order to reduce such an interaction of radiologists, we further developed a CADx system using derived imaging findings based on calculated image features, in which the system only requires few user operations. The purpose of this study is to check whether calculated image features (CFT) or derived imaging findings (DFD) can represent information in imaging findings annotated by radiologists (AFD).
Methods
We calculate 2282 image features and derive 39 imaging findings by using information on a nodule position and its type (solid or ground-glass). These image features are categorized into shape features, texture features and imaging findings-specific features. Each imaging finding is derived based on each corresponding classifier using random forest. To check whether CFT or DFD can represent information in AFD, under an assumption that the accuracies of classifiers are the same if information included in input is the same, we constructed classifiers by using various types of information (CTT, DFD and AFD) and compared accuracies on an inferred diagnosis of a nodule. We employ SVM with RBF kernel as classifier to infer a diagnosis name.
Results
Accuracies of classifiers using DFD, CFT, AFD and CFT \(+\) AFD were 0.613, 0.577, 0.773 and 0.790, respectively. Concordance rates between DFD and AFD of shape findings, texture findings and surrounding findings were 0.644, 0.871 and 0.768, respectively.
Conclusions
The results suggest that CFT and AFD are similar information and CFT represent only a portion of AFD. Particularly, CFT did not contain shape information in AFD. In order to decrease an interaction of radiologists, a development of a method which overcomes these problems is necessary.
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Acknowledgements
This work is partly supported by the Innovative Techno-Hub for Integrated Medical Bio-imaging of the Project for Developing Innovation Systems, from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
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K. Togashi has received research grants from Bayer AG, DAIICHI SANKYO Group, Eisai Co., Ltd., FUJIFILM Holdings Corporation, Nihon Medi-Physics Co., Ltd., Shimadzu Corporation, Toshiba Corporation and Covidien AG. M. Kawagishi, B. Chen, D. Furukawa, G. Aoyama, Y. Iizuka, K. Nakagomi and H. Yamamoto are Canon Inc. employees. The other authors declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.
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Informed consent was obtained from all individual participants included in the study.
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Kawagishi, M., Chen, B., Furukawa, D. et al. A study of computer-aided diagnosis for pulmonary nodule: comparison between classification accuracies using calculated image features and imaging findings annotated by radiologists. Int J CARS 12, 767–776 (2017). https://doi.org/10.1007/s11548-017-1554-0
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DOI: https://doi.org/10.1007/s11548-017-1554-0