Abstract
Purpose
As a promising intravascular therapeutic approach for autonomous catheterization, especially for thrombosis treatment, a microrobot or robotic catheter driven by an external electromagnetic actuation system has been recently investigated. However, the three-dimensional (3D) real-time position and orientation tracking of the microrobot remains a challenge for precise feedback control in clinical applications owing to the micro-size of the microrobot geometry in vessels, along with bifurcation and vulnerability. Therefore, in this paper, we propose a 3D posture recognition method for the unmanned microrobotic surgery driven by an external electromagnetic actuator system.
Methods
We propose a real-time position and spatial orientation tracking method for a millimeter-sized intravascular object or microrobot using a principal component analysis algorithm and an X-ray reconstruction. The suggested algorithm was implemented to an actual controllable wireless microrobot system composed of a bullet-shaped object, a biplane X-ray imaging device, and an electromagnetic actuation system. Numerical computations and experiments were conducted for the performance verification.
Results
The experimental results showed a good performance of the implemented system with tracking errors less than 0.4 mm in position and 2° in orientation. The proposed tracking technique accomplished a fast processing time, ~ 0.125 ms/frame, and high-precision recognition of the micro-sized object.
Conclusions
Since the suggested method does not require pre-information of the object geometry in the human body for its 3D shape and position recognition, it could be applied to various elliptical shapes of the microrobot system with computation time efficacy and recognition accuracy. Hence, the method can be used for therapeutic millimeter- or micron-sized manipulator recognition in vascular, as well as implanted objects in the human body.
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References
World Health Organization (2015) Noncommunicable diseases progress monitor 2015
Dharmarajah B (2015) European Congress of Radiology, p 1
Bashir R, Zack CJ, Zhao H, Comerota AJ, Bove AA (2014) Comparative outcomes of catheter-directed thrombolysis plus anticoagulation vs anticoagulation alone to treat lower-extremity proximal deep vein thrombosis. JAMA Intern Med 174:1494–1501. https://doi.org/10.1001/jamainternmed.2014.3415
Bowdle A (2014) Vascular complications of central venous catheter placement: evidence-based methods for prevention and treatment. J Cardiothorac Vasc Anesth 28:358–368
Nelson BJ, Kaliakatsos IK, Abbott JJ (2010) Microrobots for minimally invasive medicine. Annu Rev Biomed Eng 12:55–85. https://doi.org/10.1146/annurev-bioeng-010510-103409
Belharet K, Folio D, Ferreira A (2010) 3D MRI-based predictive control of a ferromagnetic microrobot navigating in blood vessels. In: 2010 3rd IEEE RAS and EMBS international conference on biomedical robotics and biomechatronics, BioRob 2010, pp 808–813
Climent J, Hexsel RA (2012) Particle filtering in the Hough space for instrument tracking. Comput Biol Med 42:614–623. https://doi.org/10.1016/j.compbiomed.2012.02.007
Lugez E, Sadjadi H, Joshi CP, Akl SG, Fichtinger G (2017) Improved electromagnetic tracking for catheter path reconstruction with application in high-dose-rate brachytherapy. Int J Comput Assist Radiol Surg 12:681–689
Oh J, Park JO, Park S, Ko SY (2015) Image-based guidance system for intravascular microrobot: Fiducial marker-based registration using biplanar fluoroscopic images and CTA images. In: 2015 15th international conference on control, automation and systems (ICCAS), pp 919–922
Brattain LJ, Loschak PM, Tschabrunn CM, Anter E, Howe RD (2014) Instrument tracking and visualization for ultrasound catheter guided procedures. In: Augmented environments for computer-assisted interventions, pp 41–50
Saxena A, Driemeyer J, Ng AY (2009) Learning 3-d object orientation from images. In Robotics and Automation. In: ICRA’09. 2009 IEEE international conference on robotics and automation, pp 794–800
Nakabo Y, Ishi I, Ishikawa M (2002) 3D tracking using two high-speed vision systems. In: Proceedings of IEEE/RSJ international conference on intelligent robots and systems, pp 360–365
Tognarelli S, Castelli V, Ciuti G, Di Natali C, Sinibaldi E, Dario P, Menciassi A (2012) Magnetic propulsion and ultrasound tracking of endovascular devices. J Robot Surg 6:5–12. https://doi.org/10.1007/s11701-011-0332-1
Iaquinto JM, Kindig MW, Haynor DR, Vu QB, Pepin N, Tsai R, Sangeorzan BJ, Ledoux WR (2018) Model-based tracking of the bones of the foot: a biplane fluoroscopy validation study. Comput Biol Med 92:118–127. https://doi.org/10.1016/j.compbiomed.2017.11.006
Fitzgibbon A, Pilu M, Fisher RB (1999) Direct least square fitting of ellipses. IEEE Trans Pattern Anal Mach Intell 21:476–480. https://doi.org/10.1109/34.765658
Benjamin JR, Jayasree T (2018) Improved medical image fusion based on cascaded PCA and shift invariant wavelet transforms. Int J Comput Assist Radiol Surg 13:229–240
Wijewickrema SNR, Paplinski AP (2005) Principal component analysis for the approximation of a fruit as an ellipse. In: Proceedings of 13th international conference central Europe on computer graphics, visualization and computer vision, pp 1–6
Baur C, Milletari F, Belagiannis V, Navab N, Fallavollita P (2016) Automatic 3D reconstruction of electrophysiology catheters from two-view monoplane C-arm image sequences. Int J Comput Assist Radiol Surg 11:1319–1328
Nguyen PB, Park JO, Park S, Ko SY (2016) Medical micro-robot navigation using image processing-blood vessel extraction and X-ray calibration. In Proceedings of the IEEE RAS and EMBS international conference on biomedical robotics and biomechatronics, vol 2016, pp 365–370
Richard Harltey AZ (2004) Multiple view geometry in computer vision. Cambridge University Press, Cambridge
Jeong S, Choi H, Go G, Lee C, Lim KS, Sim DS, Jeong MH, Ko SY, Park JO, Park S (2016) Penetration of an artificial arterial thromboembolism in a live animal using an intravascular therapeutic microrobot system. Med Eng Phys 38:403–410
Mönnich H, Stein D, Raczkowsky J, Wörn H (2010) An automatic and complete self-calibration method for robotic guided laser ablation. In: Proceedings of IEEE international conference on robotics and automation, pp 1086–1087
Horn BKP (1987) Closed-form solution of absolute orientation using unit quaternions. J Opt Soc Am A 4:629. https://doi.org/10.1364/JOSAA.4.000629
Stein D, Moennich H, Raczkowsky J, Woern H (2009) IEEE automatic and hand guided self-registration between a robot and an optical tracking system. In: ICAR 2009 14th international conference on advanced robotics, vol 1–2, pp 13–17
Funding
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. 2015M3D5A1065682). Seong Young Ko, for this work, was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B03933079).
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Nguyen, P.B., Kang, B., Bappy, D.M. et al. Real-time microrobot posture recognition via biplane X-ray imaging system for external electromagnetic actuation. Int J CARS 13, 1843–1852 (2018). https://doi.org/10.1007/s11548-018-1846-z
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DOI: https://doi.org/10.1007/s11548-018-1846-z