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DVH-based inverse planning for LDR pancreatic brachytherapy

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Pancreatic cancer is one of the common types of malignant cancer. Low-dose-rate (LDR) brachytherapy has shown great efficacy in curing pancreatic cancer. However, a long preoperative planning time and an insufficient tumor dose are common issues. In this paper, we present and validate a method for inverse planning using simulated annealing (SA) for the treatment of pancreatic cancer.

Methods

The SA method was used for the inverse planning process. With the help of parallel computation and a quick dose field estimation algorithm. This method allowed inverse planning to be performed quickly. A novel length-control method was used to consider and limit the dose of the organ at risk. The effect of this system was validated by calculating the dose-volume histogram metric and time consumption.

Results

Regarding the percentage of the volume receiving 100% of the prescribed dose (V100), this approach yielded an average difference in V100 of 5.01% for the tumor and of 1.32% for the organ at risk in the small tumor group; in the large tumor group, the average difference in V100 was 2.3% for the tumor and − 4.49% for the organ at risk. The average time required for inverse planning was 1.63 ± 0.26 s for small tumors and 3.81 ± 0.51 s for large tumors. Compared with other inverse planning methods, the optimal quality of the plans yielded by this method was further improved.

Conclusion

This paper presents a new type of inverse planning method for the treatment of pancreatic cancer based on SA. Compared with other LDR inverse planning methods, the method presented here can provide the prescribed dose to the tumor while considering the dose of the organ at risk. Also, the required time is significantly lower than other methods. All the experimental results indicate that this method is ready to be applied in further clinical studies.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (Grant Number 81871457) and National Natural Science Foundation of China (Grant Number 8167071354).

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Authors and Affiliations

  1. School of Mechanical Engineering, Tianjin University, 135 Yaguan Road, Jinnan District, Tianjin, 300350, China

    Zeyang Zhou, Zhiyong Yang, Shan Jiang, Yuhua Li & Tao Zhu

  2. Department of Interventional Ultrasound, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China

    Xiaoling Yu & Erpeng Qi

Authors
  1. Zeyang Zhou
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  2. Zhiyong Yang
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  3. Shan Jiang
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  4. Xiaoling Yu
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  5. Erpeng Qi
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  6. Yuhua Li
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  7. Tao Zhu
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Correspondence to Shan Jiang.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Zhou, Z., Yang, Z., Jiang, S. et al. DVH-based inverse planning for LDR pancreatic brachytherapy. Int J CARS 17, 609–615 (2022). https://doi.org/10.1007/s11548-021-02543-6

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  • DOI: https://doi.org/10.1007/s11548-021-02543-6

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