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Deep feature extraction via adaptive collaborative learning for drusen segmentation from fundus images

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Abstract

Drusen are an early sign of non-neovascular age-related macular degeneration which is a major factor of irreversible blindness. Drusen segmentation plays a vital role in proper diagnosis and prevention of further complications. However, most of the existing drusen segmentation approaches rely on handcrafted features which are not always guaranteed to be discriminative and therefore lead to limited performance. In this paper, we propose a deep feature extraction framework for drusen segmentation. It is formulated as a deep model which can automatically extract discriminative features. Specifically, the framework is mainly composed of three components, including feature learning, loss function and classification. The effectiveness of our method lies in the fact that the deep feature learning procedures are driven by an adaptive collaborative similarity learning technique in loss function. We evaluate the framework on STARE and DRIVE datasets, and the quantitative comparison with the state-of-the-art methods in terms of sensitivity, specificity and accuracy demonstrates the superiority of the proposed method.

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References

  1. Al-Hussaini, H., Schneiders, M., Lundh, P., Jeffery, G.: Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells. Exp. Eye Res. 88(3), 610–612 (2009)

    Article  Google Scholar 

  2. Belkin, M., Niyogi, P.: Laplacian eigenmaps and spectral techniques for embedding and clustering. In: Advances in neural information processing systems, pp. 585–591 (2002)

  3. Chang, C.C., Lin, C.J.: LIBSVM: a library for support vector machines. ACM Trans. Intell. Syst. Technol. 2, 27:1–27:27 (2011)

    Article  Google Scholar 

  4. Chatfield, K., Simonyan, K., Vedaldi, A., Zisserman, A.: Return of the devil in the details: delving deep into convolutional nets. In: Proceedings of the British Machine Vision Conference. BMVA Press (2014)

  5. Cheng, J., Wong, D. W. K., Cheng, X., Liu, J., Tan, N. M., Bhargava, M., Cheung, C. M. G., Wong, T. Y.: Early age-related macular degeneration detection by focal biologically inspired feature. In: International Conference on Image Processing, pp. 2805–2808. IEEE (2012)

  6. Deepak, K.S., Chakravarty, A., Sivaswamy, J.: Visual saliency based bright lesion detection and discrimination in retinal images. In: International Symposium on Biomedical Imaging, pp. 1436–1439. IEEE (2013)

  7. Dong, X., Zhu, L., Song, X., Li, J., Cheng, Z.: Adaptive collaborative similarity learning for unsupervised multi-view feature selection. In: Proceedings of the 27th International Joint Conference on Artificial Intelligence, pp. 2064–2070. AAAI Press (2018)

  8. Drive-digital retinal images for vessel extraction. https://www.isi.uu.nl/Research/Databases/DRIVE/. Accessed 23 July 2019

  9. Fan, K.: On a theorem of weyl concerning eigenvalues of linear transformations. Proc. Natl. Acad. Sci. U. S. A. 35(11), 652–655 (1949)

    Article  MathSciNet  Google Scholar 

  10. Huang, L., Zhao, Yg, Yang, Tj: Skin lesion segmentation using object scale-oriented fully convolutional neural networks. Signal Image Video Process. 13(3), 431–438 (2019)

    Article  Google Scholar 

  11. Jager, R.D., Mieler, W.F., Miller, J.W.: Age-related macular degeneration. N. Engl. J. Med. 358(24), 2606–2617 (2008)

    Article  Google Scholar 

  12. Khowaja, S.A., Khuwaja, P., Ismaili, I.A.: A framework for retinal vessel segmentation from fundus images using hybrid feature set and hierarchical classification. Signal Image and Video Process. 13(2), 379–387 (2019)

    Article  Google Scholar 

  13. Kim, Y.J., Kim, K.G.: Automated segmentation methods of drusen to diagnose age-related macular degeneration screening in retinal images. Comput. Math. Methods Med. Comput. Math. Methods Med. 2018, 1–8 (2018)

    MATH  Google Scholar 

  14. Litjens, G., Kooi, T., Bejnordi, B.E., Setio, A.A.A., Ciompi, F., Ghafoorian, M., Van Der Laak, J.A., Van Ginneken, B., Sánchez, C.I.: A survey on deep learning in medical image analysis. Med. Image Anal. 42, 60–88 (2017)

    Article  Google Scholar 

  15. Liu, H., Xu, Y., Wong, D. W. K., Liu, J.: Effective drusen segmentation from fundus images for age-related macular degeneration screening. In: Asian Conference on Computer Vision, pp. 483–498. Springer (2014)

  16. Mohar, B., Alavi, Y., Chartrand, G., Oellermann, O.: The Laplacian spectrum of graphs. Graph Theory Combin. Appl. 2(871–898), 12 (1991)

    Google Scholar 

  17. Rapantzikos, K., Zervakis, M., Balas, K.: Detection and segmentation of drusen deposits on human retina: potential in the diagnosis of age-related macular degeneration. Med. Image Anal. 7(1), 95–108 (2003)

    Article  Google Scholar 

  18. Ren, X., Zheng, Y., Zhao, Y., Luo, C., Wang, H., Lian, J., He, Y.: Drusen segmentation from retinal images via supervised feature learning. IEEE Access 6, 2952–2961 (2018)

    Article  Google Scholar 

  19. Ronneberger, O., Fischer, P., Brox, T.: U-net: Convolutional networks for biomedical image segmentation. In: International Conference on Medical image computing and computer-assisted intervention, pp. 234–241. Springer (2015)

  20. Schmitz-Valckenberg, S., Steinberg, J.S., Fleckenstein, M., Visvalingam, S., Brinkmann, C.K., Holz, F.G.: Combined confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography imaging of reticular drusen associated with age-related macular degeneration. Ophthalmology 117(6), 1169–1176 (2010)

    Article  Google Scholar 

  21. Seddon, J.M., Sharma, S., Adelman, R.A.: Evaluation of the clinical age-related maculopathy staging system. Ophthalmology 113(2), 260–266 (2006)

    Article  Google Scholar 

  22. Sui, X., Zheng, Y., Wei, B., Bi, H., Wu, J., Pan, X., Yin, Y., Zhang, S.: Choroid segmentation from optical coherence tomography with graph edge weights learned from deep convolutional neural networks. Neurocomputing 237(MAY10), 332–341 (2017)

    Article  Google Scholar 

  23. Stare-structured analysis of the retina. http://cecas.clemson.edu/~ahoover/stare/. Accessed 4 July 2019

  24. van Grinsven, M.J., Theelen, T., Witkamp, L., van der Heijden, J., van de Ven, J.P., Hoyng, C.B., van Ginneken, B., Sánchez, C.I.: Automatic differentiation of color fundus images containing drusen or exudates using a contextual spatial pyramid approach. Biomed. Opt. Express 7(3), 709–725 (2016)

    Article  Google Scholar 

  25. Yan, F., Cui, J., Wang, Y., Liu, H., Liu, H., Wei, B., Yin, Y., Zheng, Y.: Deep random walk for drusen segmentation from fundus images. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 48–55. Springer (2018)

  26. Zhang, J., Saha, A., Zhu, Z., Mazurowski, M.A.: Hierarchical convolutional neural networks for segmentation of breast tumors in mri with application to radiogenomics. IEEE Trans. Med. Imag. 38(2), 435–447 (2019)

    Article  Google Scholar 

  27. Zhu, P., Zuo, W., Zhang, L., Hu, Q., Shiu, S.C.: Unsupervised feature selection by regularized self-representation. Pattern Recognit. 48(2), 438–446 (2015)

    Article  Google Scholar 

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Acknowledgements

This work has been supported by the National Natural Science Foundation of China (61373149, 61672329).

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Correspondence to Xiangwei Zheng.

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Ren, X., Zheng, X., Dong, X. et al. Deep feature extraction via adaptive collaborative learning for drusen segmentation from fundus images. SIViP 15, 895–902 (2021). https://doi.org/10.1007/s11760-020-01812-2

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  • DOI: https://doi.org/10.1007/s11760-020-01812-2

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