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Tri-parent Baby Technology and Preservation of Lineage: An Analysis from the Perspective of Maqasid al-Shari’ah Based Islamic Bioethics

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Abstract

Tri-parent baby technology is an assisted reproductive treatment which aims to minimize or eliminate maternal inheritance of mutated mitochondrial DNA (mtDNA). The technology became popular following the move by the United Kingdom in granting license to a group of researchers from the Newcastle Fertility Centre, Newcastle University to conduct research on the symptoms of defective mtDNA. This technology differs from other assisted reproductive technology because it involves the use of gamete components retrieved from three different individuals. Indirectly, it affects the preservation of lineage which is important from an Islamic point of view. This paper aims to analyze and discuss the implications of the tri-parent technology on preservation of lineage from the perspective of Maqasid al-Shari’ah based the Islamic bioethics. The analysis shows that there are a few violations of the preservation of lineage, hence the tri-parent baby technology should not be permitted.

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References

  • Abduljabbar, H. S., & Amin, R. (2009). Assisted reproductive technology in Saudi Arabia. Saudi Medical Journal, 30(4), 461–464.

    Google Scholar 

  • Abdullah, A. B. (2014). An analysis of Islamic Jurisprudence (Fiqh) as applied Islamic ethics. Islam and Civilisational Renewal, 5(2), 183–203.

    Article  Google Scholar 

  • Adi Setia. (2015). Freeing maqāṣid & maṣlaḥah from surreptitious utilitarianism. This paper was presented at the International Conference on the Applications of Maqasid Al-Shari‘ah (Objectives Of The Shari‘ah) in Governance and Public Policy, Kuala Lumpur.

  • Ahmad, R. (2004). Standard maslahah dan mafsadah dalam penentuan hukum Islam semasa di Malaysia. (Unpublished Ph.D. Thesis). Kuala Lumpur: Universiti Malaya.

  • Akhmad, S. A., & Rosita, L. (2012). Islamic bioethics: The art of decision making. Indonesian Journal of Legal and Forensic Sciences, 2(1), 8–12.

    Google Scholar 

  • Allahbadia, G. N. (2015). Is the World of ART Ready for a Ménage à Trois? The Journal of Obstetrics and Gynecology of India, 65(2), 71–74.

    Article  Google Scholar 

  • al-Bar, M. A., & Chamsi-Pasha, H. (2015). Contemporary bioethics: Islamic perspective. London: Springer.

    Book  Google Scholar 

  • al-Buti, M. S. (1973). Dawabit al-maslahah fi al-Shari’ah al-Islamiyyah. Beirut: Muassasah al-Risalah.

    Google Scholar 

  • al-Fawwaz, T. S. (2013). al-Tatbiqat at-tibbiyyah ‘ala al-qawa’id al-fiqhiyyah. Riyadh: Dar al-Atlas al-Khadhra’.

    Google Scholar 

  • al-Ghazzali, A. H. (n.d.). Al-Mustaṣfā min al-ʿIlm al-Uṣūl. In H. Z. Hafiz (Eds.), (Vol. 2). Madinah: Syarkah al-Madinah al-Munawwara li al-Tiba'ah.

  • al-Suyuti, J. A. (1997). al-Ashbah wa al-Nazair fi Qawaíd wa Furu’ al-Shafiíyyah. Makkah: Maktabah Nizar Mustafa al-Baz.

    Google Scholar 

  • al-Yubi, M. S. (2011). Maqasid al-Shari’ah al-Islamiyyah wa ‘Alaqatuha bi al-Adillah al-Tasyri’iyyah. Riyadh: Dar Ibn al-Jauzi.

    Google Scholar 

  • Amin, L., Sujak, S. F., Ramlee, S. N. S., Samian, A. L., Haron, M. S., & Mohamad, M. N. (2011). Educating the Ummah by introducing Islamic bioethics in genetics and modern biotechnology. Procedia Social and Behavioral Sciences, 15, 3399–3403.

    Article  Google Scholar 

  • Arbach, O. (2002). Ethical considerations in Syria regarding reproduction techniques. Medicine and Law, 21, 395–401.

    Google Scholar 

  • Ashur, M. a.-T. (2001). Maqasid al-Shari'ah al-Islamiyyah. Amman: Dar al-Nafaes.

  • Auda, J. (2010). Maqāṣid al-Sharīʿah as philosophy of Islamic law: A systems approach. Kuala Lumpur: Islamic Book Trust & The International Institute of Islamic Thought.

    Google Scholar 

  • Auda, J. (2014). Mudahnya Maqasid Syariah. (M.B. Hamid, Trans.). Kuala Lumpur: PTS Islamika.

  • Baylis, F. (2013). The ethics of creating children with three genetic parents. Reproductive BioMedicine Online, 26(6), 531–534.

    Article  Google Scholar 

  • Baylis, F. (2017). Human nuclear genome transfer (So-called mitochondrial replacement): Clearing the underbrush. Bioethics, 31(1), 7–19.

    Article  Google Scholar 

  • Bender, K., Schneider, P. M., & Rittner, C. (2000). Application of mtDNA sequence analysis in forensic casework for the identification of human remains. Forensic Science International, 113, 103–107.

    Article  Google Scholar 

  • Bredenoord, A. L., & Braude, P. (2011). Ethics of mitochondrial gene replacement: From bench to bedside. BMJ, 342, 87–89.

    Google Scholar 

  • Chapra, M. U. (2008). The Islamic vision of development in the light of Maqāsid al-sharī‘ah. Jeddah: Islamic Development Bank.

    Google Scholar 

  • Chiaratti, M. R., Meirelles, F. V., Wells, D., & Poulton, J. (2011). Therapeutic treatments of mtDNA diseases at the earliest stages of human development. Mitochondrion, 11, 820–828.

    Article  Google Scholar 

  • Claiborne, A., English, R., & Kahn, J. (2016). Mitochondrial replacement techniques: Ethical, social, and policy considerations. Washington: The National Academies Press.

    Book  Google Scholar 

  • Coble, M. D., Loreille, O. M., Wadhams, M. J., Edson, S. M., Maynard, K., Meyer, C. E., et al. (2009). Mystery solved: The identification of the two missing romanov children using DNA analysis. PLoS ONE, 4(3), e4838. doi:10.1371/journal.pone.0004838.

    Article  Google Scholar 

  • Craven, L., Tuppen, H. A., Greggains, G. D., Harbottle, S. J., Murphy, J. L., Cree, L. M., et al. (2010). Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature, 465, 82–87.

    Article  Google Scholar 

  • Dar al-Ifta al-Misriyyah. (2017). My husband can’t have children. Is it allowed in Islam to seek fertilization with donor sperm? Dar al-Ifta al-Misriyyah, from http://eng.dar-alifta.org/foreign/ViewFatwa.aspx?ID=6962. Accessed January 27, 2017.

  • Darnovsky, M. (2013). A slippery slope to human germline modification. Nature, 499, 127.

    Article  Google Scholar 

  • Daud, M. (1995). Perkahwinan menurut Islam. Kuala Lumpur: Utusan Publications and Distributors.

    Google Scholar 

  • Dimauro, S., & Davidzon, G. (2005). Mitochondrial DNA and disease. Annals of Medicine, 37, 222–232.

    Article  Google Scholar 

  • Dusuki, A. W., & Abozaid, A. (2007). A critical appraisal on the challenges of realizing Maqasid al-Shariah. IIUM Journal of Economics and Management, 15(2), 143–165.

    Google Scholar 

  • El-Hashemite, N. (1997). The Islamic view in genetic preventive procedures. The Lancet, 350, 223.

    Article  Google Scholar 

  • Ghaly, M. (2013). Islamic bioethics in the twenty-first century. Zygon, 48(3), 592–599.

    Article  Google Scholar 

  • Gill, P., Ivanov, P. L., Kimpton, C., Piercy, R., Benson, N., Tully, G., et al. (1994). Identification of the remains of the Romanov family by DNA analysis. Nature Genetics, 6, 130–135.

    Article  Google Scholar 

  • Haimes, E., & Taylor, K. (2015). Rendered invisible? The absent presence of egg providers in U.K. debates on the acceptability of research and therapy for mitochondrial disease. Monash Bioethics Review, 33, 360–378.

    Article  Google Scholar 

  • Hashi, A. A. (2015). Bioethics: A comparative study of its concept, issues and approaches. Kuala Lumpur: IIUM Press.

    Google Scholar 

  • Hellebrekers, D., Wolfe, R., Hendrickx, A., de Coo, I., de Die, C., Geraedts, J., et al. (2012). PGD and heteroplasmic mitochondrial DNA point mutations: a systematic review estimating the chance of healthy offspring. Human Reproduction Update, 18(4), 341–349.

    Article  Google Scholar 

  • Herbrand, C. (2017). Mitochondrial replacement techniques: Who are the potential users and will they benefit? Bioethics, 31(1), 46–54.

    Article  Google Scholar 

  • Holland, M., & Parsons, T. (1999). Mitochondrial DNA sequence analysis—Validation and use for forensic casework. Forensic Science Review, 11(1), 21–50.

    Google Scholar 

  • Holt, I., Harding, A., & Morgan-Hughes, J. (1988). Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature, 331(25), 717–719.

    Article  Google Scholar 

  • House of Lords Hansard. (2008). Lords Hansard, www.parliament.uk: http://www.publications.parliament.uk/pa/ld200708/ldhansrd/text/80204-0002.htm. Accessed August 4, 2014.

  • Human Fertilisation and Embryology Authority. (2005). HFEA grants licence to Newcastle Centre at LIFE for Mitochondrial Research. Human Fertilisation and Embryology Authority, from http://www.hfea.gov.uk/671.html. Accessed August 4, 2014.

  • Human Fertilisation and Embryology Authority. (2014). Third scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception: 2014 update. London: Human Fertilisation and Embryology Authority.

    Google Scholar 

  • Human Fertilisation and Embryology Authority. (2015). Statement on mitochondrial donation. Human Fertilisation and Embryology Authority, from http://www.hfea.gov.uk/9606.html. Accessed March 30, 2015.

  • Ibrahim, A. H., Rahman, N. N. A., & Saifuddeen, S. M. (2016). Advances in tri-parent baby technology: The bioethical challenge for Muslims. In M. H. Kamali, O. Bakar, D. A.-F. Batchelor, & R. Hashim (Eds.), Islamic perspectives on science and technology: Selected conference papers (pp. 289–299). Singapore: Springer.

    Chapter  Google Scholar 

  • Inhorn, M. C. (2006). Making Muslim babies: IVF and gamete donation. Culture, Medicine and Psychiatry, 30, 427–450.

    Article  Google Scholar 

  • Ishii, T. (2014). Potential impact of human mitochondrial replacement on global policy regarding germline gene modification. Reproductive BioMedicine Online, 29(2), 150–155.

    Article  Google Scholar 

  • Islam, S. (2013). Ethics of assisted reproductive medicine: A comparative study of western secular and Islamic bioethics. London: The International Institute of Islamic Thought.

    Google Scholar 

  • Jenuth, J., Peterson, A., Fu, K., & Shoubridge, E. (1996). Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nature Genetics, 14, 146–151.

    Article  Google Scholar 

  • Kasule, O. H. (2015). A medical perspective on preservation of human progeny. In S. M. Saifuddeen (Ed.), Preservation of human progeny in the age of biotechnology (pp. 45–56). Kuala Lumpur: Institut Kefahaman Islam Malaysia.

    Google Scholar 

  • Legge, M., & Fitzgerald, R. (2013). Numerical identity: The creation of tri-parental embryos to correct inherited mitochondrial disease. The New Zealand Medical Journal, 126(1385), 71–75.

    Google Scholar 

  • Meirelles, F., & Smith, L. (1997). Mitochondrial genotype segregation in a mouse heteroplasmic lineage produced by embryonic karyoplast transplantation. Genetics, 145, 445–451.

    Google Scholar 

  • Meirelles, F., & Smith, L. (1998). Mitochondrial genotype segregation during preimplantation development in mouse heteroplasmic embryos. Genetics, 148, 877–884.

    Google Scholar 

  • Mitalipov, S., & Wolf, D. P. (2014). Clinical and ethical implications of mitochondrial gene transfer. Trends in Endocrinology and Metabolism, 25(1), 5–7.

    Article  Google Scholar 

  • Moosa, E. (2003). Human cloning in Muslim ethics. Voices Across Boundaries, 23–26.

  • Muslim World League Islamic Fiqh Council. (2006). Resolutions of Islamic Fiqh Council Makkah Mukarramah. Makkah Mukarramah: Muslim World League Islamic Fiqh Council, from http://themwl.org/downloads/Resolutions-of-Islamic-Fiqh-Council-1.pdf. Accessed March 30, 2016.

  • Nesbitt, V., Alston, C. L., Blakely, E. L., Fratter, C., Feeney, C. L., Poulton, J., et al. (2014). A national perspective on prenatal testing for mitochondrial disease. European Journal of Human Genetics, 22, 1255–1259.

    Article  Google Scholar 

  • Nisker, J. (2015). The latest thorn by any other name: Germ-line nuclear transfer in the name of “mitochondrial replacement”. Journal of Obstetrics and Gynaecology Canada, 37(9), 829–831.

    Article  Google Scholar 

  • Nor, S. N. M. (2010). Human genetic technologies and Islamic bioethics. In G. Pfleiderer, G. Brahier, & K. Lindpaintner (Eds.), GenEthics and religion (pp. 129–137). Basel: Karger.

    Chapter  Google Scholar 

  • Nordin, M. M. (2012). An Islamic perspective of assisted reproductive technologies. Bangladesh Journal of Medical Science, 11(4), 252–257.

    Article  Google Scholar 

  • Nordin, M. M. (2015). Islamic medical ethics amidst developing biotechnologies. In S. M. Saifuddeen (Ed.), Preservation of human progeny in the age of biotechnology (pp. 57–72). Kuala Lumpur: Institut Kefahaman Islam Malaysia.

    Google Scholar 

  • Nuffield Council on Bioethics. (2012). Novel techniques for the prevention of mitochondrial DNA disorders: An ethical reviews. London: Nuffield Council on Bioethics.

    Google Scholar 

  • Omar, A.M. (2013). Kedudukan anak tak sah taraf: Dari aspek pandangan Syarak, nasab dan pewarisan serta kekeluargaan Islam. This paper was presented at Kempen ‘Sah Nikah, Sah Nasab’, Bangi, Selangor.

  • Palacios-Gonzalez, C. (2016). Mitochondrial replacement techniques: Egg donation, genealogy and eugenics. Monash Bioethics Review, 34, 37–51.

    Article  Google Scholar 

  • Pfeffer, G., Majamaa, K., Turnbull, D., Thorburn, D., & Chinnery, P. (2012). Treatment for mitochondrial disorders. Cochrane Database of Systematic Reviews (4), 1–39.

  • Poulton, J., & Bindoff, L. (2008). Mitochondrial respiratory chain disorders. In J. Boeke et al. (Eds.), Encyclopedia of life sciences (Vol. 12, pp. 126–133). West Sussex: Wiley.

    Google Scholar 

  • Poulton, J., & Oakeshott, P. (2012). Nuclear transfer to prevent maternal transmission of mitochondrial DNA disease. BMJ, 345, 1–2.

    Article  Google Scholar 

  • Primorac, D., Andelinovic, S., Definis-Gojanovic, M., Drmic, I., Rezic, B., Baden, M., et al. (1996). Identification of war victims from mass graves in Croatia, Bosnia, and Herzegovina by use of standard forensic methods and DNA typing. Journal of Forensic Sciences, 41(5), 891–894.

    Article  Google Scholar 

  • Rahman, F. (2015). Kesihatan dan perubatan dalam tradisi Islam: Perubahan dan identiti. (W.M. Daud, & S.A. Abdullah, Trans.). Kuala Lumpur: Dewan Bahasa dan Pustaka.

  • Raquib, A. (2015). Islamic ethics of technology. Kuala Lumpur: The Other Press.

    Google Scholar 

  • Sachedina, A. A. (2009). Islamic biomedical ethics : Principles and application. New York: Oxford University Press.

    Book  Google Scholar 

  • Saey, T. H. (2016). Risk identified in procedure for ‘three-parent babies’. ScienceNews, 189(13), 8.

    Google Scholar 

  • Saifuddeen, S. M., Rahman, N. N. A., Isa, N. M., & Baharuddin, A. (2014). Maqasid al-Shariah as a complementary framework to conventional bioethics. Science Engineering Ethics, 20, 317–327.

    Article  Google Scholar 

  • Sallevelt, S. C., Dreesen, J. C., Drüsedau, M., Spierts, S., Coonen, E., Tienen, F. H., et al. (2013). Preimplantation genetic diagnosis in mitochondrial DNA disorders: Challenge and success. Journal of Medical Genetics, 50, 125–132.

    Article  Google Scholar 

  • Salman, S. (2015). Ethical and Legal Thought on Mitochondrial Donation. Research Center for Islamic Legislation and Ethics, from http://www.cilecenter.org/en/articles-essays/ethical-and-legal-thought-on-mitochondrial-donation/. Accessed January 11, 2016.

  • Schaefer, A. M., Taylor, R. W., Turnbull, D. M., & Chinnery, P. F. (2004). The epidemiology of mitochondrial disorders—past, present and future. Biochimica et Biophysica Acta, 1659, 115–120.

    Article  Google Scholar 

  • Schaefer, G. B., & Thompson, J. N., Jr. (2014). Medical genetics: An integrated approach. New York: McGraw-Hill Education.

    Google Scholar 

  • Scully, J. L. (2017). A mitochondrial story: Mitochondrial replacement, identity and narrative. Bioethics, 31(1), 37–45.

    Article  Google Scholar 

  • Serour, G. I. (2008). Islamic perspectives in human reproduction. Reproductive BioMedicine Online, 17(3), 34–38.

    Article  Google Scholar 

  • Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D. M., Ma, H., et al. (2013). Towards germline gene therapy of inherited mitochondrial diseases. Nature, 493, 627–631.

    Article  Google Scholar 

  • Tachibana, M., Sparman, M., Sritanaudomchai, H., Ma, H., Clepper, L., Woodward, J., et al. (2009). Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature, 461, 367–372.

    Article  Google Scholar 

  • Taylor, R. W., & Turnbull, D. M. (2005). Mitochondrial DNA mutations in human disease. Nature Reviews Genetics, 6(5), 389–402.

    Article  Google Scholar 

  • Thorburn, D. R. (2004). Mitochondrial disorders: Prevalence, myths and advances. Journal of Inherited Metabolic Disease, 27(3), 349–362.

    Article  Google Scholar 

  • Treff, N. R., Campos, J., Tao, X., Levy, B., Ferry, K. M., & Scott, R. T., Jr. (2012). Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder. Fertility and Sterility, 98(5), 1236–1240.

    Article  Google Scholar 

  • Tur-Kaspa, I., Jeelani, R., & Doraiswamy, P. M. (2014). Preimplantation genetic diagnosis for inherited neurological disorders. Nature Reviews Neurology, 10, 417–424.

    Article  Google Scholar 

  • Uthman, M. R. (2012). al-Jinum: Qadaya fiqhiyyah. Kaherah: Dar al-Kutub al-Misriyyah.

    Google Scholar 

  • Wallace, D. C., & Chalkia, D. (2013). Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease. Cold Spring Harbor Perspectives in Biology, 5(11), 1–47.

    Article  Google Scholar 

  • Wallace, D. C., Singh, G., Lott, M. T., Hodge, J. A., Schurr, T. G., Lezza, A. M., et al. (1988). Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy. Science, 242, 1427–1430.

    Article  Google Scholar 

  • Yamada, M., Emmanuele, V., Sanchez-Quintero, M. J., Sun, B., Lallos, G., Paull, D., et al. (2016). Genetic drift can compromise mitochondrial replacement by nuclear transfer in human oocytes. Cell Stem Cell, 18(6), 749–754.

    Article  Google Scholar 

  • Zhang, J., Liu, H., Luo, S., Chavez-Badiola, A., Liu, Z., Yang, M., et al. (2016). First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh Syndrome. Fertility and Sterility, 106(3), e375–e376.

    Article  Google Scholar 

  • Zhang, J., Liu, H., Luo, S., Lu, Z., Chávez-Badiola, A., Liu, Z., et al. (2017). Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reproductive Biomedicine Online, 34, 361–368.

    Article  Google Scholar 

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Ibrahim, A.H., Rahman, N.N.A., Saifuddeen, S.M. et al. Tri-parent Baby Technology and Preservation of Lineage: An Analysis from the Perspective of Maqasid al-Shari’ah Based Islamic Bioethics. Sci Eng Ethics 25, 129–142 (2019). https://doi.org/10.1007/s11948-017-9980-5

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