Skip to main content
Log in

Blood vessel extraction in fundus images using hessian eigenvalues and adaptive thresholding

  • Special Issue
  • Published:
Evolutionary Intelligence Aims and scope Submit manuscript

Abstract

Retinal image blood vessels are having significant role in different eye related diseases such as diabetic retinopathy, glaucoma, cataract, age-related macular degeneration and many more. Vasculature retinal feature extraction is an important factor to different doctors for treatment and diagnosis of different diseases. For automatic extraction of retinal blood vessels, different types of clustering related approaches (i.e. k-means/fuzzy c-means) are introduced to explore blood vessels from real time retinal images. Novel blood vessel extraction approach is introduced to explore retinal blood vessels with unsupervised clustering procedures like fuzzy c-means followed with Gabor filter. In this paper, we propose Enhanced blood vessel exploration approach (EBVEA) to improve the segmentation and visualization of vasculature retinal images or fundus images in blood vessel extraction with a combination of hessian based center-to boundary (BB) filters. These filters are used to indicate elongated boundary structures by enhancing the functions based on hessian Eigen values represented in (nxn) matrix. Performance of proposed enhanced approach with traditional approaches in terms of true positive rate (tpr), accuracy etc. are tested. Experimental results carried out and tested on bench mark data sets like DRIVE and STARE datasets produced better results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Yavuz Z, Köse C (2017) Blood vessel extraction in color retinal fundus images with enhancement filtering and unsupervised classification. Hindawi J Healthc Eng. https://doi.org/10.1155/2017/4897258

    Article  Google Scholar 

  2. Saffarzadeh VM, Osareh A, Shadgar B (2014) Vessel segmentation in retinal images using multi-scale line operator and K-means clustering. J Med Signals Sens 4(2):122

    Article  Google Scholar 

  3. Oliveira WS, Teixeira JV, Ren TI, Cavalcanti GDC, Sijbers J (2016) Unsupervised retinal vessel segmentation using combined filters. PLoS ONE 11(2):e0149943

    Article  Google Scholar 

  4. Utrecht (2015) Digital retinal image for vessel extraction (DRIVE). http://www.isi.uu.nl/Research/Databases/DRIVE/

  5. Dey N, Roy AB, Pal M, Das A (2012) FCM based blood vessel segmentation method for retinal images. Int J Comput Sci Netw 1(3). arXiv:1209.1181

  6. Nguyen UTV, Bhuiyan A, Park LAF, Ramamohanarao K (2013) An effective retinal blood vessel segmentation method using multi-scale line detection. Pattern Recogn 46(3):703–715

    Article  Google Scholar 

  7. Budai A, Bock R, Maier A, Hornegger J, Michelson G (2013) Robust vessel segmentation in fundus images. Int J Biomed Imaging 2013:154860

    Article  Google Scholar 

  8. Sharma S, Wasson EV (2015) Retinal blood vessel segmentation using fuzzy logic. J Netw Commun Emerg Technol 4(3):1–5

    Google Scholar 

  9. Shah SAA, Tang TB, Faye I, Laude A (2017) Blood vessel segmentation in color fundus images based on regional and Hessian features. Graefe’s Arch Clin Exp Ophthal 255:1525–1533

    Article  Google Scholar 

  10. Jerman T, Pernuš F, Likar B, Špiclin Z (2016) Enhancement of vascular structures in 3D and 2D angiographic images. IEEE Trans Med Imaging 35:2107–2118

    Article  Google Scholar 

  11. Jerman T, Pernuš F, Likar B, Špiclin Z (2015) Blob enhancement and visualization for improved intracranial aneurysm detection. IEEE Trans Vis Comput Gr 22:1705–1717

    Article  Google Scholar 

  12. G Himabindu, Prasad reddy PVGD, Murty MRK (2018) Classification of kidney lesions using bee swarm optimization. Int J Eng Technol 7(2.33):1046–1052

    Google Scholar 

  13. Himabindu G, Prasad reddy PVGD, Murty MRK (2018) Extraction of texture features and classification of renal masses from kidney images. Int J Eng Technol 7(2):1057–1063

    Google Scholar 

  14. Rudyanto RD, Kerkstra S et al (2014) Comparing algorithms for automated vessel segmentation in computed tomography scans of the lung: the VESSEL12 study. Med Image Anal 18(7):1217–1232

    Article  Google Scholar 

  15. Goyal A, Lee J, Lamata P, van den Wijngaard J, van Horssen P, Spaan J, Siebes M, Grau V, Smith N (2013) Model-based vasculature extraction from optical fluorescence cryomicrotome images. IEEE Trans Med Imaging 32(1):56–72

    Article  Google Scholar 

  16. Baka N, Metz C, Schultz C, van Geuns R-J, Niessen W, van Walsum T (2014) Oriented gaussian mixture models for nonrigid 2D/3D coronary artery registration. IEEE Trans Med Imaging 33(5):1023–1034

    Article  Google Scholar 

  17. Zhang B, Zhang L, Zhang L, Karray F (2010) Retinal vessel extraction by matched filter with first-order derivative of Gaussian. Comput Biol Med 40(4):438–445

    Article  Google Scholar 

  18. Odstrcilik J, Kolar R, Budai A, Hornegger J, Jan J, Gazarek J, Kubena T, Cernosek P, Svoboda O, Angelopoulou E (2013) Retinal vessel segmentation by improved matched filtering: evaluation on a new high-resolution fundus image database. IET Image Process 7(4):373–383

    Article  MathSciNet  Google Scholar 

  19. Luu HM, Klink C, Moelker A, Niessen W, van Walsum T (2015) Quantitative evaluation of noise reduction and vesselness filters for liver vessel segmentation on abdominal CTA images. Phys Med Biol 60(10):3905–3926

    Article  Google Scholar 

  20. Huang F, Dashtbozorg B, Tan T, ter Haar Romeny BM (2018) Retinal artery/vein classification using genetic-search feature selection. Comput Methods Programs Biomed 161:197–207

    Article  Google Scholar 

  21. Tyler Coye (2020) Novel retinal vessel segmentation algorithm: fundus images. MATLAB Central File Exchange. https://www.mathworks.com/matlabcentral/fileexchange/50839-novel-retinal-vessel-segmentation-algorithm-fundus-images. Retrieved 6 Jan 2020

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to P. V. G. D. Prasad Reddy.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Prasad Reddy, P.V.G.D. Blood vessel extraction in fundus images using hessian eigenvalues and adaptive thresholding. Evol. Intel. 14, 577–582 (2021). https://doi.org/10.1007/s12065-019-00329-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12065-019-00329-z

Keywords

Navigation