Abstract
Type 2 diabetes mellitus is a serious metabolic disorder affecting global health and results in number of serious life-threatening complications leading to increased mortality rate. Complications can be prevented with early diagnosis and appropriate care. International Diabetes Federation and World Health Organization suggested an urgent need of national level actions to prevent type 2 diabetes. The adverse effects of adherence to drugs as antidiabetic agents at later stages cannot be avoided. Hence, alternative therapies are constantly explored by the researchers to mitigate type 2 diabetes. Exercise has a significant impact on the improvement of type 2 diabetes. Metabolic adaptations are provoked by exercise in skeletal muscle cells. AMP-activated protein kinase (AMPK) is an important molecule in managing these adaptations. In response to cellular energy demand, the activity of AMPK increases, which then triggers the glucose transporter 4 (GLUT4) translocation through signaling pathways proposed in the present model. The quantification of exercise on insulin resistance reduction is not well established. The modeling of the effects of physical exercise on signaling pathways in the disease condition is still a challenging task. In silico studies are useful to investigate effect of exercise in diabetes. This research work presents a model to quantify the effect of exercise on the GLUT4 translocation. The result provides effect of exercise in the improvement of insulin resistance developed by type 2 diabetes. The study is useful for establishing in vivo model correlating actual effect of exercise in diabetes management.
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Acknowledgements
The authors are thankful to Nirma University, Ahmedabad, Gujarat, India for providing necessary facilities to carry out the research work, which is a part of Doctor of Philosophy (Ph.D.) research work of Darshna M. Joshi, to be submitted to Nirma University, Ahmedabad, Gujarat, India.
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Joshi, D.M., Patel, J. & Bhatt, H. In silico study to quantify the effect of exercise on surface GLUT4 translocation in diabetes management. Netw Model Anal Health Inform Bioinforma 10, 1 (2021). https://doi.org/10.1007/s13721-020-00274-3
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DOI: https://doi.org/10.1007/s13721-020-00274-3