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A platform for restriction mapping

https://doi.org/10.1016/S0743-1066(96)00118-5Get rights and content
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Abstract

Restriction mapping involves finding certain sites on a DNA molecule. Biologists perform a variety of experiments to obtain data that are subject to error of method. The diversity of experimental data makes restriction mapping a complicated synthesis of information processing and constraint satisfaction. We present a theoretical framework that treats constraints for the various techniques in a homogeneous and consistent manner. Our implementation is written in CLP(R), includes the main techniques used by biologists, and encourages the building of maps incrementally. We also show how to consider more recent experimental techniques in the framework.

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Supported by Australian Research Council grant A49330684 and a Monash University FCIT grant.