The Gene Ontology

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Abstract

The Gene Ontology (GO) project provides a structured, controlled terminology’ of ‘terms’ or ‘classes’ describing the functions of gene products, as well as the association of these terms with the gene products performing these functions. It is specifically designed for supporting the computational representation of biological systems. The combination of solid conceptual underpinnings and tools for its use have made the GO a widely popular resource in the biological and bioinformatics research community and an essential resource for computational data analysis. This article describes the structure of the Gene Ontology, the semantic meaning of annotations, and an overview of typical uses of the Gene Ontology.

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Pascale Gaudet works in the field of biocuration since 2003, working on various projects, including the Model Organism Database dictyBase, the neXtProt database on human proteins of the Swiss Institute of Bioinformatics (SIB), and the Gene Ontology project. Since 2017 Pascale Gaudet is the Project Manager of the GO project. Additionally, Pascale Gaudet is one of the founding members and the first chairperson of the International Society for Biocuration (ISB). The ISB seeks to connect biocurators, developers, and researchers with an interest in biocuration, both amongst themselves and with the users and funders of biological informatics resources.

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