Elsevier

Journal of Biomedical Informatics

Volume 51, October 2014, Pages 114-128
Journal of Biomedical Informatics

Histology image search using multimodal fusion

https://doi.org/10.1016/j.jbi.2014.04.016Get rights and content
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Abstract

This work proposes a histology image indexing strategy based on multimodal representations obtained from the combination of visual features and associated semantic annotations. Both data modalities are complementary information sources for an image retrieval system, since visual features lack explicit semantic information and semantic terms do not usually describe the visual appearance of images. The paper proposes a novel strategy to build a fused image representation using matrix factorization algorithms and data reconstruction principles to generate a set of multimodal features. The methodology can seamlessly recover the multimodal representation of images without semantic annotations, allowing us to index new images using visual features only, and also accepting single example images as queries. Experimental evaluations on three different histology image data sets show that our strategy is a simple, yet effective approach to building multimodal representations for histology image search, and outperforms the response of the popular late fusion approach to combine information.

Graphical abstract

Highlights

  • A novel framework for building multimodal representations for histology images.

  • Combination of visual features and semantic annotations using linear transformations of data.

  • Learning transformation functions between the two data modalities.

  • Automatic prediction of the semantic representation for new images.

  • Experimental validation on three different histology image databases.

Keywords

Histology
Digital pathology
Image search
Multimodal fusion
Visual representation
Semantic spaces

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Work done while at Universidad Nacional de Colombia.