Elsevier

NeuroImage

Volume 144, Part B, January 2017, Pages 262-269
NeuroImage

The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository: Structural and functional MRI, MEG, and cognitive data from a cross-sectional adult lifespan sample

https://doi.org/10.1016/j.neuroimage.2015.09.018Get rights and content
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Highlights

  • Cross-sectional uniform adult-lifespan population-based data

  • Multimodal MRI, fMRI and MEG neuroimaging data

  • Unprecedented depth of cognitive phenotyping

  • Age-related differences in brain structure, function, and cognition

Abstract

This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort. The Cam-CAN Stage 2 repository contains multi-modal (MRI, MEG, and cognitive-behavioural) data from a large (approximately N = 700), cross-sectional adult lifespan (18–87 years old) population-based sample. The study is designed to characterise age-related changes in cognition and brain structure and function, and to uncover the neurocognitive mechanisms that support healthy cognitive ageing. The database contains raw and preprocessed structural MRI, functional MRI (active tasks and resting state), and MEG data (active tasks and resting state), as well as derived scores from cognitive behavioural experiments spanning five broad domains (attention, emotion, action, language, and memory), and demographic and neuropsychological data. The dataset thus provides a depth of neurocognitive phenotyping that is currently unparalleled, enabling integrative analyses of age-related changes in brain structure, brain function, and cognition, and providing a testbed for novel analyses of multi-modal neuroimaging data.

Abbreviations

ACE-R
Addenbrooke's Cognitive Exam
BOLD
blood-oxygenation level-dependent
Cam-CAN
Cambridge Centre for Ageing and Neuroscience
DARTEL
diffeomorphic anatomical registration through exponentiated lie algebra
DWI
diffusion-weighted imaging
DTI
diffusion tensor imaging
DKI
diffusion kurtosis imaging
ERF
event-related field
fMRI
[functional] magnetic resonance imaging
GM
grey matter
MNI
Montreal Neurological Institute
MT
magnetisation transfer
MEG
magnetoencephalography
MMSE
Mini Mental Status Exam
ROI
region of interest
VBM
voxel-based morphometry
WMS-III UK
Wechsler Memory Scale Third UK Edition
WM
white matter

Keywords

Data repository
Brain imaging
Magnetic resonance imaging
Magnetoencephalography
Cognition
Ageing

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