Model-based Bayesian inference of brain oxygenation using quantitative BOLD

Highlights

• Streamlined qBOLD can produce quantitative measurements of brain oxygenation.

• A non-linear qBOLD model was implemented in a Bayesian framework.

• Bayesian non-linear model fitting of simulated data reproduces, DBV and OEF estimates reliably.

• Testing on in vivo data is consistent with previously published ASEqBOLD data.

• The model can be extended to include additional signal compartments.

Abstract

Streamlined Quantitative BOLD (sqBOLD) is an MR technique that can non-invasively measure physiological parameters including Oxygen Extraction Fraction (OEF) and deoxygenated blood volume (DBV) in the brain. Current sqBOLD methodology rely on fitting a linear model to log-transformed data acquired using an Asymmetric Spin Echo (ASE) pulse sequence. In this paper, a non-linear model implemented in a Bayesian framework was used to fit physiological parameters to ASE data. This model makes use of the full range of available ASE data, and incorporates the signal contribution from venous blood, which was ignored in previous analyses. Simulated data are used to demonstrate the intrinsic difficulty in estimating OEF and DBV simultaneously, and the benefits of the proposed non-linear model are shown. In vivo data are used to show that this model improves parameter estimation when compared with literature values. The model and analysis framework can be extended in a number of ways, and can incorporate prior information from external sources, so it has the potential to further improve OEF estimation using sqBOLD.