Cloud computing is the major paradigm in today's IT world with the capabilities of security management, high performance, flexibility, scalability. Customers valuing these features can better benefit if they use a cloud environment built using HPC fabric architecture. However, security is still a major concern, not only on the software side but also on the hardware side. There are multiple studies showing that the malicious users can affect the regular customers through the hardware if they are co-located on the same physical system. Therefore, solving possible security concerns on the HPC fabric architecture will clearly make the fabric industries leader in this area. In this paper, we propose an autonomic HPC fabric architecture that leverages both resilient computing capabilities and adaptive anomaly analysis for further security.