It is know that kinds inputting method are used in inputting system of computer. We found some of them are used in mobile phones these years. According to the development of mobile technology, mobile phone functions were increased. Users not only call with phones, but also send e-mail to each other. There are four methods what have been applied in Japan. They are Common, Intelligent, Two-Key and T9. This paper introduces a novel way to evaluate the four existing different methods of mobile phones. We did the mobile phone experiment for comparing the difference of the four inputting methods. Then, we measured all the subjects' physiological indices, and etc. We put the main emphasis on physiological results in the paper. We used the physiological indices to compare the methods of mobile phone e-mail function usage. The results tell us the characters and the difference of every inputting method and the affect on human body.