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Adaptively Banded Smith-Waterman Algorithm for Long Reads and Its Hardware Accelerator | IEEE Conference Publication | IEEE Xplore

Adaptively Banded Smith-Waterman Algorithm for Long Reads and Its Hardware Accelerator


Abstract:

In this paper, we propose hardware-compatible Adaptively Banded Smith-Waterman algorithm (ABSW) to align long genomic sequences. By utilizing banded Smith-Waterman algori...Show More

Abstract:

In this paper, we propose hardware-compatible Adaptively Banded Smith-Waterman algorithm (ABSW) to align long genomic sequences. By utilizing banded Smith-Waterman algorithm to align subsequences of fixed lengths, ABSW finds alignment of a pair of arbitrarily long sequences with constant memory. In addition, a heuristic algorithm, dynamic overlapping, is proposed to make overlaps of bands of subsequences to improve accuracy. To enable hardware acceleration of ABSW, we further propose the hardware architecture of banded Smith-Waterman with traceback. Experiments show that ABSW produces near optimal alignment scores for sequences with up to 40% error rates. Our hardware implementation of ABSW demonstrates more than 200× speedup over software implementation.
Date of Conference: 10-12 July 2018
Date Added to IEEE Xplore: 26 August 2018
ISBN Information:
Electronic ISSN: 2160-052X
Conference Location: Milan, Italy

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