Abstract:
Cancer of the pancreas is a highly lethal disease and has an extremely poor prognosis. Mathematical modelling and computer simulations have been proposed as important too...Show MoreMetadata
Abstract:
Cancer of the pancreas is a highly lethal disease and has an extremely poor prognosis. Mathematical modelling and computer simulations have been proposed as important tool to predictor initiation and progression of cancer diseases, which are very important in cancer study. Among these studies, it is widely assumed that the gene mutation rate is unchanged, which is not realistic based on recently biological and medical studies. In this work, we present a new approach using non-constant mutation rate and hence reveal several important biological parameters of cancer progression. Under more realistic assumptions regarding gene mutation and a more reasonable mutation rate, our proposed model and calculated results may provide insights into dynamics of cancer metastasis and have clinic implications.
Date of Conference: 13-16 November 2017
Date Added to IEEE Xplore: 18 December 2017
ISBN Information: