Abstract:
Merkel Cell Polyomavirus (MCV) is associated with more than 80% of Merkel cell carcinoma (MCC), a rare but highly lethal form of skin cancer. We made use of the immunolog...Show MoreMetadata
Abstract:
Merkel Cell Polyomavirus (MCV) is associated with more than 80% of Merkel cell carcinoma (MCC), a rare but highly lethal form of skin cancer. We made use of the immunological data on MCV available through publications and databases and constructed MCV T cell Antigen Database (MCVdb). MCVdb contains 734 curated antigen entries of MCV antigenic proteins and 30 experimentally verified T cell epitopes. The data were subject to extensive quality control (redundancy elimination, error detection, and vocabulary consolidation). A set of computational tools for in-depth analysis, such as sequence comparison using BLAST search, multiple alignments of antigens, and T cell epitope conservation analysis have been integrated within the MCVdb. Predicted Class I and Class II HLA-binding peptides for 15 common HLA alleles are included in this database as putative targets. MCVdb is a unique data source providing a comprehensive list of MCV antigens and peptides. MCVdb is publicly available at http://projects.met-hilab.org/mcv/.
Date of Conference: 13-16 November 2017
Date Added to IEEE Xplore: 18 December 2017
ISBN Information: