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Pysubsim-tree: A package for simulating tumor genomes according to tumor evolution history | IEEE Conference Publication | IEEE Xplore

Pysubsim-tree: A package for simulating tumor genomes according to tumor evolution history


Abstract:

Next-generation sequencing (NGS) and the third generation sequencing (TGS) have recently allowed us to develop algorithms to quantitatively dissect the extent of heteroge...Show More

Abstract:

Next-generation sequencing (NGS) and the third generation sequencing (TGS) have recently allowed us to develop algorithms to quantitatively dissect the extent of heterogeneity within a tumour, resolve cancer evolution history and identify the somatic variations and aneuploidy events. Simulation of tumor NGS and TGS data serves as a powerful and cost-effective approach for benchmarking these algorithms, however, there is no available tool that could simulate all the distinct subclonal genomes with diverse aneuploidy events and somatic variations according to the given tumor evolution history. We provide a simulation package, Pysubsim-tree, which could simulate the tumor genomes according to their evolution history defined by the somatic variations and aneuploidy events. Pysubsim-tree is free, open source, available at: https://github.com/dustincys/pysubsimtree
Date of Conference: 13-16 November 2017
Date Added to IEEE Xplore: 18 December 2017
ISBN Information:
Conference Location: Kansas City, MO, USA

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