Visualizing High-dimensional single-cell RNA-sequencing data through multiple Random Projections | IEEE Conference Publication | IEEE Xplore

Visualizing High-dimensional single-cell RNA-sequencing data through multiple Random Projections


Abstract:

Recent sequencing technology breakthroughs have resulted in a dramatic increase in the amount of available sequencing data, enabling major scientific advances in biology ...Show More

Abstract:

Recent sequencing technology breakthroughs have resulted in a dramatic increase in the amount of available sequencing data, enabling major scientific advances in biology and medicine. Nowadays, sequencing transcriptome data of single cells (scRNA-seq) are growing rapidly, posing new challenges in their analysis, mostly due to their high dimensionality. In this paper, we study the problem of visualizing such high-dimensional scRNA-seq data. A new visualization scheme is presented based on a customized distance matrix retrieved by applying independently Nearest Neighbors search through multiple Random Projections. The proposed method is compared against well-known dimensionality reduction and visualization techniques showing its capabilities and performance.
Date of Conference: 10-13 December 2018
Date Added to IEEE Xplore: 24 January 2019
ISBN Information:
Conference Location: Seattle, WA, USA

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