Online advertising is widely used by commercial companies to attract customers. Tuning advertisement delivery to achieve a high conversion rate (CVR) is crucial for improving advertising effectiveness. Because advertisers require demandside platforms (DSPs) to deliver a certain number of ads within a fixed period, it is challenging to maximize CVR while satisfying ads delivery constraints. Such a combinatorial optimization problem is NP-hard when we have a considerable number of both ads and users. In this paper, we adopt Digital Annealer (DA), a quantum-inspired Ising computer, to solve the combinatorial optimization problem. The experimental evaluation result shows that the proposed method increases accuracy from 0.176 to 0.326 and achieves 20.8 times speed-up compared to baseline.