This paper presents a programmable wireless platform for biomedical signal acquisition application. The platform includes 8-channel programmable low-noise frontend circuits, a 12-bit SAR ADC, a digital control and processing unit (DCPU), and a RF transceiver. The number of the readout channels in the platform can be programmable according to the requirements of the applications. And the platform can support a maximum number of 64 readout channels with 8 pieces of low-noise frontend circuits. The platform circuits were implemented in a 0.18μm CMOS technology. The low-noise frontend shows an input-referred noise of 1.6μVrms integrated across 1-200Hz with 18.4μA current consumption per channel. The SAR ADC exhibits an effective number of bits (ENOB) of 10.2bit with 450μA power consumption at the maximum conversion rate up to 1Msps.