In this paper, we present the Profile Extraction (PE) algorithm, which allows the computation of a multi-channel profile highly correlated with voluntary muscle activity. This event-based profile can be used as biomimetic control during the calibration phase of a Functional Electrical Stimulation (FES) system. The adoption of the PE technique represents the preliminary step to extend the applicability of our event-driven paradigm to control the coordinated multi-joint movements. Through an experimental campaign, we tested the improvements made by the use of PE in the FES calibration, assessing the reproducibility between the voluntary and stimulated movements. Results show a 2 % increase of the median correlation value for a single-channel exercise and a 3.6 % increase for a dual-channel one. A statistical decrease of normalized Root Mean Square Error has been obtained for the dual-channel exercise (p < 0.05).